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| | 1,2,3,4,5,6-HEXABROMOCYCLOHEXANE Basic information |
| Product Name: | 1,2,3,4,5,6-HEXABROMOCYCLOHEXANE | | Synonyms: | 1,2,3,4,5,6-hexabromo-cyclohexan;1,2,3,4,5,6-HEXABROMOCYCLOHEXANE;BENZENE HEXABROMIDE;JAK2 INHIBITOR II;trans-α-Benzene hexabromide;1,2,3,4,5,6-Hexabromcyclohexan;NSC 7908;JAK2 Inhibitor II - CAS 1837-91-8 - Calbiochem | | CAS: | 1837-91-8 | | MF: | C6H6Br6 | | MW: | 557.54 | | EINECS: | | | Product Categories: | | | Mol File: | 1837-91-8.mol |  |
| | 1,2,3,4,5,6-HEXABROMOCYCLOHEXANE Chemical Properties |
| | 1,2,3,4,5,6-HEXABROMOCYCLOHEXANE Usage And Synthesis |
| Uses | 1,2,3,4,5,6-Hexabromocyclohexane is a potent and specific inhibitor of JAK2 autophosphorylation. | | Definition | ChEBI: 1,2,3,4,5,6-hexabromocyclohexane is a bromohydrocarbon that is cyclohexane in which the hydrogen at positions 1,2,3,4,5 and 6 have been replaced by bromo groups. It is a potent inhibitor of JAK2 tyrosine kinase autophosphorylation. It has a role as an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor. It is a bromohydrocarbon and a bromoalkane. It derives from a hydride of a cyclohexane. | | Biological Activity | Potently and directly inhibits JAK2 tyrosine kinase autophosphorylation, specifically inhibiting ligand-dependent JAK2 activation. A 16-hour treatment with 1 μ M of compound reduces JAK2 tyrosine autophosphorylation levels to ~ 50% while 50 μ M elimates nearly all JAK2 activity. Non-cytotoxic at 100 μ M. | | storage | Room temperature |
| | 1,2,3,4,5,6-HEXABROMOCYCLOHEXANE Preparation Products And Raw materials |
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