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Prucalopride Impurity 1

Prucalopride Impurity 1 Basic information
Product Name:Prucalopride Impurity 1
Synonyms:Prucalopride Impurity65;7-Benzofurancarboxamide, 4-amino-5-chloro-N-[1-(3-methoxypropyl)-4-piperidinyl]-;4-?Amino-?5-?chloro-?N-?[1-?(3-?methoxypropyl)?-?4-?piperidinyl]?-7-?benzofurancarboxamid?e;Prucalopride Succinate iMpuritP;Prucalopride Impurity 04
CAS:1900715-96-9
MF:C18H24ClN3O3
MW:365.85
EINECS:
Product Categories:
Mol File:1900715-96-9.mol
Prucalopride Impurity 1 Structure
Prucalopride Impurity 1 Chemical Properties
Boiling point 527.2±50.0 °C(Predicted)
density 1.29±0.1 g/cm3(Predicted)
pka13.13±0.20(Predicted)
Safety Information
MSDS Information
Prucalopride Impurity 1 Usage And Synthesis
Uses4-?Amino-?5-?chloro-?N-?[1-?(3-?methoxypropyl)?-?4-?piperidinyl]?-7-?benzofurancarboxamid?e is an impurity of Prucalopride Succinate (P838950(P)), which is a selective 5-HT4 receptor agonist used effective for chronic constipation, but is not currently approved in the U.S. Prucalopride is approved for the treatment of chronic constipation in Europe. In a more recent analytical study, 4-?Amino-?5-?chloro-?N-?[1-?(3-?methoxypropyl)?-?4-?piperidinyl]?-7-?benzofurancarboxamid?e was selectively separated and characterized as a process impurity of Prucalopride Succinate (P838950(P)) under stress conditions.
Prucalopride Impurity 1 Preparation Products And Raw materials
Prucalopride Impurity 4 Prucalopride Impurity 11 Prucalopride Impurity 10/ethyl 4-(4-amino-5-chloro-2,3-dihydrobenzofuran-7-carboxamido)piperidine-1-carboxylate Methyl 4-(acetylaMino)-3-broMo-2-(2-broMoethoxy)-5-chlorobenzoate Prucalopride Impurity 32
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