Diltiazem impurity

Diltiazem impurity Basic information
Product Name:Diltiazem impurity
Synonyms:(2S,3S)-5-(2-Aminoethyl)-2,3-dihydro-3-hydroxy-2-(4-hydroxyphenyl)-1,5-benzothiazepin-4(5H)-one;Diltiazem EP Impurity H;Diltiazem Impurity 8(Diltiazem EP Impurity H);Diltiazem impurity;Diltiazem Impurity H;Diltiazem Impurity H (N,N,O-Tridesmethyl Desacetyl Diltiazem);(2S,3S)-2-hydroxy-3-(4-methoxyphenyl)-3-[2-(β-N,N-dimethylaminoethylamino)phenylthio]propionic acid;Diltiazem EP Impurity H/ Diltiazem Related Compound H (N,N,O-Tri-Desmethyl Desacetyl Diltiazem)
CAS:115992-91-1
MF:C17H18N2O3S
MW:330.4
EINECS:
Product Categories:
Mol File:115992-91-1.mol
Diltiazem impurity Structure
Diltiazem impurity Chemical Properties
Melting point 121 - 128°C
Boiling point 648.4±55.0 °C(Predicted)
density 1.365±0.06 g/cm3(Predicted)
storage temp. -20°C Freezer, Under inert atmosphere
solubility DMSO (Slightly), Methanol (Slightly, Sonicated)
pka9.81±0.30(Predicted)
form Solid
color White to Light Yellow
Safety Information
MSDS Information
Diltiazem impurity Usage And Synthesis
Uses(2S,3S)-5-(2-Aminoethyl)-2,3-dihydro-3-hydroxy-2-(4-hydroxyphenyl)-1,5-benzothiazepin-4(5H)-one is an impurity of diltiazem (D460620). Diltiazem Hydrochloride is a calcium channel blocker with vasodilating activity. Anti-anginal; anti-hypertensive; anti-arrhythmic (class IV).
Diltiazem impurity Preparation Products And Raw materials
O-Desacetyl-N-desmethyl Diltiazem Diltiazem Impurity 5 diltiazem hydrochloride Diltiazem EP Impurity C N,N,O-Tridesmethyl Diltiazem (2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one DESACETYL DILTIAZEM HCL Diltiazem Impurity 8 brinzolamide Diltiazem N-Oxide N,N-Didesmethyl Diltiazem Hydrochloride Deacetyl Diltiazem N-Oxide (2R-cis)-3-acetoxy-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one monohydrochloride Diltiazem hydrochloride Diltiazem Impurity 4 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-, (2S-trans)- O-Desmethyl Diltiazem Hydrochloride Desacetyl DiltiazeM-d4

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