ChemicalBook Product Catalog Organic Chemistry Amides Acyclic polyamines and their derivatives Alverine citrate

Alverine citrate

Alverine citrate Basic information
Product Name:Alverine citrate
Synonyms:Alverine base or citrate;alverine dihydrogen citrate;Profenil citrate;AntispasMin;CalMabel;n-ethyl-3,3'-diphenyldipropylamine citrate;N-ETHYL-3,3'-DIPHENYLDIPROPYLAMINE CITRATE SALT;N-ETHYL-3,3-DIPHENYLDIPROPYLAMINE CITRATE SALT
CAS:5560-59-8
MF:C26H35NO7
MW:473.57
EINECS:226-929-3
Product Categories:Pharmaceutical intermediates;SPASMAVERINE;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:5560-59-8.mol
Alverine citrate Structure
Alverine citrate Chemical Properties
Melting point 100-102°
storage temp. 2-8°C
solubility Slightly soluble in water and in methylene chloride, sparingly soluble in ethanol (96 per cent).
form neat
color White to Off-White
InChIKeyRYHCACJBKCOBTJ-UHFFFAOYSA-N
CAS DataBase Reference5560-59-8(CAS DataBase Reference)
Safety Information
Safety Statements 24/25
WGK Germany 3
HS Code 29214990
MSDS Information
ProviderLanguage
SigmaAldrich English
Alverine citrate Usage And Synthesis
Chemical PropertiesWhite or almost white, crystalline powder.
OriginatorAlverine citrate,Kemikos
Usesanticholinergic
UsesAn adrenergic-β3 receptor agonist. Antispasmodic.
UsesUsed for studies of pharmacological activity including:
  • Synergism with fluconazole against Saccharomyces cerevisiae and Candida albicans
  • Efficacy of combination with simeticone on abdominal pain associated with irritable bowel syndrome
  • Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis
  • Drug effects viewed from a signal transduction network perspective
  • Enhanced cytotoxic effect of proteasome inhibitor MG132
  • Mechanism of action on phasic smooth muscles
DefinitionChEBI: The citrate salt of alverine, resulting from the reaction of equimolar amounts of alvarine and citric acid. An antispasmodic that acts directly on intestinal and uterine smooth muscle, it is used in the treatment of irritable bowel syndrome.
Manufacturing Process2 Methods of producing of alverine:
1. 3-Phenylpropylchloride reacted with ethylamine in the presence potassium hydroxide and N-ethyl-3,3'-diphenyldipropylamine (alverine) was obtained.
2. 3-Phenylpropenal reacted with ethylamine in the presence hydrogen and Pt as catalyst and BaSO4 and N-ethyl-3,3'-diphenyldipropylamine (alverine) was obtained.
In practice it is usually used as citrate.


Therapeutic FunctionAnticholinergic, Spasmolytic
Alverine citrate Preparation Products And Raw materials
Raw materialsBarium sulfate-->Ethylamine-->Hydrogen-->1-Chloro-3-phenylpropane-->Potassium hydroxide-->Platinum-->PLATINUM BARIUM SULFATE
CITRATE ALVERINE CITRATE IMPURITY STANDARD SOLUTION 3-HYDROXY-3-METHYLGLUTARIC ACID 2-Hydroxy-2-methylbutyric acid ALVERINE CITRATE IMP. D (EP) AS HYDROCHLORIDE: N-(3-CYCLOHEXYLPROPYL)-N-ETHYL-3-PHENYL-PROPAN-1-AMINE HYDROCHLORIDE Alverine citrate ALVERINE CITRATE IMP. A (EP): 1-CHLORO-3-PHENYL-PROPANE Mosapride Citrate Tablet (-)-2-[METHYLAMINO]-1-PHENYLPROPANE D/L-AMPHETAMINE HYDROCHLORIDE ALVERINE CITRATE IMP. B (EP): 3-PHENYLPROPAN-1-OL TAMOXIFEN CITRATE(RG) (R)-2-HYDROXY-2-METHYLBUTYRIC ACID (R)-(-)-CITRAMALIC ACID (S)-(+)-CITRAMALIC ACID Sildenafil citrate ALVERINE CITRATE IMP. C (EP) AS HYDROCHLORIDE: N-ETHYL-3-PHENYLPROPAN-1-AMINE HYDROCHLORIDE 2-ETHYL-2-HYDROXYBUTYRIC ACID
Email:[email protected] [email protected]
Copyright © 2025 Mywellwork.com All rights reserved.