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| | TRIMETHYLTIN CHLORIDE Basic information |
| | TRIMETHYLTIN CHLORIDE Chemical Properties |
| Melting point | 37-39 °C (lit.) | | Boiling point | 148 °C | | density | 0.988 g/mL at 25 °C | | Fp | 207 °F | | storage temp. | Poison room | | solubility | Chloroform (Slightly) | | form | Liquid | | Specific Gravity | 1.356 | | color | White | | Odor | Strong unpleasant stench; no threshold data available | | Water Solubility | Soluble in water, chloroform and organic solvents. | | Sensitive | Moisture Sensitive | | Hydrolytic Sensitivity | 4: no reaction with water under neutral conditions | | BRN | 3535111 | | Exposure limits | ACGIH: TWA 0.1 mg/m3; STEL 0.2 mg/m3 (Skin)
NIOSH: IDLH 25 mg/m3; TWA 0.1 mg/m3 | | Stability: | Moisture Sensitive | | InChIKey | KWTSZCJMWHGPOS-UHFFFAOYSA-M | | CAS DataBase Reference | 1066-45-1(CAS DataBase Reference) | | EPA Substance Registry System | Trimethyltin chloride (1066-45-1) |
| | TRIMETHYLTIN CHLORIDE Usage And Synthesis |
| Chemical Properties | WHITE CRYSTALS | | Uses | Trimethyltin chloride is an organotin reagent widely used in transferring trimethylstannyl groups onto the substrates to synthesize various organostannanes. Trimethylstannyl compounds derived from this reagent, are extensively used in the palladium-catalyzed Stille coupling reactions. | | General Description | Solid. | | Reactivity Profile | TRIMETHYLTIN CHLORIDE is in the family of tin compounds widely used as stabilizers for plastics, additives to paint(as antifouling agents). Some have catalytic properties. Examples include butyl tin, dibutyl tin oxide. Their main hazard is associated with their high toxicity, in skin adsorption or inhalation. | | Hazard | A deadly poison. A reproductive hazard. | | Health Hazard | (Non-Specific -- Tin Compounds, Organic) The material is an irritant to the skin and gastrointestinal tract. Contact may specifically damage the following target organs: central nervous system, eyes, liver, urinary tract, and skin. | | Health Hazard | Trimethyltin chloride and other organotin compounds are highly toxic by ingestion,
inhalation, or skin contact. Trimethyltin chloride can cause irritation and burns of the
skin and eyes. Organotin compounds can affect the central nervous system. The
degree of toxicity is greatest for compounds with three or four alkyl groups attached
to tin. Diand monoalkyltin compounds are moderately toxic. The toxicity diminishes
as the size of the alkyl groups increases. Thus, the oral LD50s in rats are as follows:
dimethyltin dichloride, 74 to 237 mg/kg; tributyltin chloride, 122 to 349 mg/kg;
dibutyltin oxide, 487 to 520 mg/kg; trioctyltin chloride, >4000 mg/kg.
Organotin compounds have been shown to cause reproductive effects in laboratory
animals. | | Fire Hazard | Not a significant fire hazard. Emits toxic fumes in fire. | | Fire Hazard | When heated to decomposition, TRIMETHYLTIN CHLORIDE emits toxic fumes of chlorides. Avoid decomposing heat. | | Flammability and Explosibility | Not a significant fire hazard. Emits toxic fumes in fire. | | Safety Profile | A deadly poison by
intravenous route. Experimental
reproductive effects. See also TIN
COMPOUNDS. When heated to
decomposition it emits toxic fumes of Cl-. | | Incompatibilities | Trimethyltin chloride and other organotin halides react with water to produce
hydrogen halides. Organotin hydrides react with water to produce hydrogen gas,
which is flammable and explosive. | | Waste Disposal | Excess trimethyltin chloride or other organotin compound and waste material containing this
substance should be placed in an appropriate container, clearly labeled, and handled according
to your institution's waste disposal guidelines. |
| | TRIMETHYLTIN CHLORIDE Preparation Products And Raw materials |
| Raw materials | Tetraallyltin-->ALLYLTRIMETHYLTIN-->DIMETHYLTIN DICHLORIDE-->METHYLMERCURY(II) CHLORIDE | | Preparation Products | 4-BROMO-2-(TRIFLUOROMETHYL)-5-METHOXYPYRIDINE-->2,6-Bis(trimethyltin)-4,8-dioctyloxybenzo[1,2-b:3,4-b]dithiophene-->3,3'-Dibromo-5,5'-bis(trimethylsilyl)-2,2'-bithiophene-->1,1'-[4,8-Bis[(2-ethylhexyl)oxy]benzo[1,2-b:4,5-b']dithiophene-2,6-diyl]bis[1,1,1-trimethylstannane] |
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