ChemicalBook Product Catalog Analytical Chemistry Standard Pharmaceutical Impurity Reference Standards 4-(4-(3-(4-chloro-3-(trifluoroMethyl)phenyl)ureido)-3-fluorophenoxy)-2-(MethylcarbaMoyl)pyridine 1-oxide

4-(4-(3-(4-chloro-3-(trifluoroMethyl)phenyl)ureido)-3-fluorophenoxy)-2-(MethylcarbaMoyl)pyridine 1-oxide

4-(4-(3-(4-chloro-3-(trifluoroMethyl)phenyl)ureido)-3-fluorophenoxy)-2-(MethylcarbaMoyl)pyridine 1-oxide Basic information
Product Name:4-(4-(3-(4-chloro-3-(trifluoroMethyl)phenyl)ureido)-3-fluorophenoxy)-2-(MethylcarbaMoyl)pyridine 1-oxide
Synonyms:4-(4-(3-(4-chloro-3-(trifluoroMethyl)phenyl)ureido)-3-fluorophenoxy)-2-(MethylcarbaMoyl)pyridine 1-oxide;Regorafenib N-Oxide (M2 Metabolite);Regorafenib N-Oxide(M2);Regorafenib N-Oxide;Regorafenib impurity M;Regorafenib Pyridine-N-Oxide;Regorafénib N-oxyde (M2);2-Pyridinecarboxamide,4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-, 1-oxide
CAS:835621-11-9
MF:C21H15ClF4N4O4
MW:498.81
EINECS:
Product Categories:
Mol File:835621-11-9.mol
4-(4-(3-(4-chloro-3-(trifluoroMethyl)phenyl)ureido)-3-fluorophenoxy)-2-(MethylcarbaMoyl)pyridine 1-oxide Structure
4-(4-(3-(4-chloro-3-(trifluoroMethyl)phenyl)ureido)-3-fluorophenoxy)-2-(MethylcarbaMoyl)pyridine 1-oxide Chemical Properties
Boiling point 580.5±50.0 °C(Predicted)
density 1.49±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: soluble
form A solid
pka12.07±0.70(Predicted)
Stability:Light Sensitive
Safety Information
MSDS Information
4-(4-(3-(4-chloro-3-(trifluoroMethyl)phenyl)ureido)-3-fluorophenoxy)-2-(MethylcarbaMoyl)pyridine 1-oxide Usage And Synthesis
UsesRegorafenib (Pyridine)-N-oxide is a synthetic metabolite of Regorafenib (R143000) and is used for treatment and prevention of cancer.
4-(4-(3-(4-chloro-3-(trifluoroMethyl)phenyl)ureido)-3-fluorophenoxy)-2-(MethylcarbaMoyl)pyridine 1-oxide Preparation Products And Raw materials
5-Nitro-1H-iMidazole-1-ethanol 2-[2-(2-Methyl-5-nitroiMidazol-1-yl)ethoxy]ethanol Regorafenib Impurity 16 Regorafenib Impurity 25 Regorafenib Impurity 6 Regorafenib Impurity 3 Regorafenib Impurity 8 4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLINAMIDE Regorafenib Impurity 7 Regorafenib N-Oxide N-Glucuronide Regorafenib Impurity 6 N-Desmethyl Regorafenib Regorafenib Impurity 4 Regorafenib Impurity 9 N-Desmethyl Regorafenib N-Oxide (M5 Metabolite) Regorafenib Impurity 5 Regorafenib N-Glucuronide Regorafenib impurity D
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