AZ20

AZ20 Basic information

Product Name:	AZ20
Synonyms:	AZ20;1H-Indole, 4-[4-[(3R)-3-methyl-4-morpholinyl]-6-[1-(methylsulfonyl)cyclopropyl]-2-pyrimidinyl]-;4-[4-[(3R)-3-Methyl-4-morpholinyl]-6-[1-(methylsulfonyl)cyclopropyl]-2-pyrimidinyl]-1H-indole AZ20;AZ20 4-[4-[(3R)-3-Methyl-4-morpholinyl]-6-[1-(methylsulfonyl)cyclopropyl]-2-pyrimidinyl]-1H-indole;4-[4-[(3R)-3-Methyl-4-morpholinyl]-6-[1-(methylsulfonyl)cyclopropyl]-2-pyrimidinyl]-1H-indole;AZ-20; AZ 20;;CS-1335;(3R)-4-[2-(3H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]-3-methylmorpholine
CAS:	1233339-22-4
MF:	C21H24N4O3S
MW:	412.51
EINECS:
Product Categories:	Inhibitors
Mol File:	1233339-22-4.mol

AZ20 Chemical Properties

Boiling point	634.6±55.0 °C(Predicted)
density	1.42±0.1 g/cm3(Predicted)
storage temp.	-20°
solubility	Soluble in DMSO (up to 20 mg/ml).
pka	15.65±0.30(Predicted)
form	solid
color	Off-white
Stability:	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.

Safety Information

MSDS Information

AZ20 Usage And Synthesis

Description	AZ20 (1233339-22-4) is a potent and highly selective inhibitor of Ataxia telangiectasia mutated and RAD3-related (ATR) kinase (IC50?= 5 nM in vitro; IC50?= 50 nM in HT29 colorectal adenocarcinoma cells).1?Combination therapy with AZ20 and gemcitabine resulted in synergistic inhibition of tumor cell growth and cell death initiation in pancreatic cancer cell lines.2
Uses	AZ20 is a potent and selective inhibitor of ATR (ATM-Rad3-related) kinase with in vivo antitumor activity.
Definition	ChEBI: (3R)-4-[2-(1H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)-4-pyrimidinyl]-3-methylmorpholine is a member of indoles.
storage	Store at -20°C
References	1) Foote?et al.?(2013)?Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): A Potent and Selective Inhibitor of ATR Protein Kinase with Monotherapy In Vivo Antitumor Activity; J. Med. Chem.?56?2125 2) Liu?et al.?(2017)?Inhibition of ATR potentiates the cytotoxic effect of gemcitabine on pancreatic cancer cell lines through enhancement of DNA damage and abrogation of ribonucleotide reductase induction by gemcitabine; Oncol. Rep.?37?3377

AZ20 Preparation Products And Raw materials

Raw materials

(R)-4-(2-chloro-6-(iodomethyl)pyrimidin-4-yl)-3-methylmorpholine-->(R)-(2-chloro-6-(3-methylmorpholino)pyrimidin-4-yl)methyl methanesulfonate-->(R)-3-Methylmorpholine-->4-Chloromethyl-2,6-dichloropyrimidine-->(R)-methyl 2-chloro-6-(3-methylmorpholino)pyrimidine-4-carboxylate-->(R)-(2-chloro-6-(3-methylmorpholino)pyrimidin-4-yl)methanol-->Indole-4-boronic acid-->2-(3-CHLOROPHENYL)MALONDIALDEHYDE

Olaparib Imiquimod Dequalinium chloride Pomalidomide VE 822 NOTUMib-1 KU-60019 VE-821 WORTMANNIN MK-2206 2HCl

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