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| | GUANABENZ Basic information |
| Product Name: | GUANABENZ | | Synonyms: | GUANABENZ;2-[(2,6-dichlorophenyl)methylene]-hydrazinecarboximidamide;n-(2,6-dichlorobenzylidene)amino]guanidine;n-(2,6-dichlorobenzylidene)-n’-amidinohydrazine;nsc-68982;Rexitene;HydrazinecarboxiMidaMide, 2-[(2,6-dichlorophenyl)Methylene]-;1-(2,6-DICHLOROBENZYLIDENEAMINO)GUANIDINE | | CAS: | 5051-62-7 | | MF: | C8H8Cl2N4 | | MW: | 231.08 | | EINECS: | 225-750-8 | | Product Categories: | | | Mol File: | 5051-62-7.mol |  |
| | GUANABENZ Chemical Properties |
| Melting point | 227-229° (dec) | | Boiling point | 353.9±52.0 °C(Predicted) | | density | 1.49±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 12 mg/mL (51.93 mM);Ethanol: 15 mg/mL (64.91 mM) | | pka | pKa 8.1 (Uncertain) | | Water Solubility | Water: Insoluble |
| Hazard Codes | Xn | | Risk Statements | 20/21/22-62 | | Safety Statements | 22-36/37/39 | | RIDADR | 3249 | | WGK Germany | 3 | | HazardClass | 6.1(b) | | PackingGroup | III |
| | GUANABENZ Usage And Synthesis |
| Description | Guanabenz is an α2-adrenergic agonist that exhibits pronounced hypotensive action, and
that is associated with a reduction of overall peripheral vascular resistance, decline in frequency
of cardiac contractions, and reduced cardiac output. | | Originator | Wytensin,Wyeth,US,1982 | | Uses | It is used both independently and in combination with oral diuretics for treating various
degrees of hypertension. | | Uses | alpha agonists | | Definition | ChEBI: Guanabenz is a dichlorobenzene. | | Manufacturing Process | A mixture of 14.0 g of 2,6-dichlorobenzaldehyde, 10.8 g of aminoguanidine
bicarbonate and 100 ml of pyridine was refluxed for 3 hours. The reaction
mixture was poured into water and the crystalline precipitate filtered off; MP
225°C to 227°C. | | Therapeutic Function | Antihypertensive | | Synthesis | Guanabenz, [(2,6-dichlorobenzyliden) amino] guanidine (22.3.1), is synthesized
in one step by reacting 2,6-dichlorobenzaldehyde with amino guanidine. 
| | Purification Methods | Crystallise the guanidine from MeCN and store it in a CO2–free atmosphere. The monoHCl [23256-5-0] has m 178o(dec) [solubility w% at 25o is 1.1(H2O), 5(EtOH), 0.1(EtOAc), 0.06(CHCl3)]. It is an antihypertensive drug. [Holmes et al. Drugs 26 212 1983.] |
| | GUANABENZ Preparation Products And Raw materials |
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