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| | Y-39983 hydrochloride Basic information |
| Product Name: | Y-39983 hydrochloride | | Synonyms: | Y 39983;4-[(1R)-1-Aminoethyl]-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide hydrochloride;Y 39983, (HCl);(594859-54-8) y 39983;4-[(1R)-1-Aminoethyl]-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide hydrochloride ISO 9001：2015 REACH;Y-39983 HCI;(R)-4-(1-Aminoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzamide hydrochloride;Y-33075 (hydrochloride) | | CAS: | 471843-75-1 | | MF: | C16H16N4O.HCl | | MW: | 316.78538 | | EINECS: | | | Product Categories: | | | Mol File: | 471843-75-1.mol |  |
| | Y-39983 hydrochloride Chemical Properties |
| storage temp. | -20°C | | solubility | DMSO: soluble | | form | A solid |
| | Y-39983 hydrochloride Usage And Synthesis |
| Description | Y-39983 hydrochloride, also known as Y-33075, is a selective Rho-associated coiled coil-forming protein kinase (ROCK) inhibitor derived from Y-27632, and is more potent than Y-27632, with an IC50 of 3.6 nM. | | in vitro | In rabbits, topical administration of Y-39983 significantly increased conventional outflow by 65.5%, followed by significant, dose-dependent reduction in IOP. Maximum IOP reduction was 13.2 ± 0.6 mm Hg (mean ± SE) at 0.1% Y-39983 in rabbits. In monkeys, at 3 hours after topical administration of 0.05% Y-39983, maximum reduction of IOP was 2.5 ± 0.8 mm Hg. No serious side effects were observed in ocular tissues except sporadic punctate subconjunctival hemorrhage during long-term topical administration of Y-39983 four times a day (at 2-hour intervals) in rabbits or monkeys. However, punctate subconjunctival hemorrhage was not observed with administration twice daily (at a 6-hour interval) or three times a day (at 5-hour intervals). | | References | [1]. Hideki Tokushige, et al. Effects of Topical Administration of Y-39983, a Selective Rho-Associated Protein Kinase Inhibitor, on Ocular Tissues in Rabbits and Monkeys Invest. Ophthalmol. Vis. Sci. July 2007 vol. 48no. 7 3216-3222 DOI:10.1167/IOVS.05-1617
[2]. Tokushige H, et al. Effects of Y-39983, a selective Rho-associated protein kinase inhibitor, on blood flow in optic nerve head in rabbits and axonal regeneration of retinal ganglion cells in rats. Curr Eye Res. 2011 Oct;36(10):964-70. DOI:10.3109/02713683.2011.599106
[3]. Watabe H, et al. Effects of Rho-associated protein kinase inhibitors Y-27632 and Y-39983 on isolated rabbit ciliary arteries.Jpn J Ophthalmol. 2011 Jul;55(4):411-7. Epub 2011 Jun 11. DOI:10.1007/s10384-011-0048-9 |
| | Y-39983 hydrochloride Preparation Products And Raw materials |
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