Amifostine Thiol Dihydrochloride

Amifostine Thiol Dihydrochloride Basic information
Product Name:Amifostine Thiol Dihydrochloride
Synonyms:Amifostine Thiol Dihydrochloride;2-[(3-Aminopropyl)amino]ethanethioldihydrochloride;Amifostine Thiol (50 mg) (2-[(3-aminopropyl)amino]ethanethiol, dihydrochloride);AMifostine Thiol;2-[(3-AMinopropyl)aMino]ethanethiol Hydrochloride;WR-1065 dihydrochloride;WR-1065 2HCl;Amifostine Thiol Dihydrochloride (90%)
CAS:14653-77-1
MF:C5H14N2S
MW:134.24306
EINECS:
Product Categories:Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Sulfur & Selenium Compounds
Mol File:14653-77-1.mol
Amifostine Thiol Dihydrochloride Structure
Amifostine Thiol Dihydrochloride Chemical Properties
Melting point 184-186°C
storage temp. -20°C
solubility H2O: ≥20mg/mL
form powder
color white to off-white
Stability:Hygroscopic
Safety Information
Hazard Codes Xn
Risk Statements 22-41
Safety Statements 26-39-41
WGK Germany 3
HS Code 2930909165
Toxicitymouse,LD50,intraperitoneal,400mg/kg (400mg/kg),European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 24, Pg. 48, 1989.
MSDS Information
Amifostine Thiol Dihydrochloride Usage And Synthesis
Chemical PropertiesWhite Solid
UsesA metabolite of Amifostine.
Biochem/physiol ActionsWR-1065 is cytoprotective cell-permeable reactive oxygen species scavenger and p53 activator and re-activator. Recently shown to have antiretroviral activity and an active metabolite of Amifostine which selectively protects normal tissues from the damaging effects of anti-neoplastic radiation therapy.
storageDesiccate at -20°C
Amifostine Thiol Dihydrochloride Preparation Products And Raw materials
Potassium di-tert-butyl phosphate 4-ETHYLCATECHOL Octyl 4-methoxycinnamate WRG-28 N,N-Diisopropylethylamine PHOSPHOENOLPYRUVIC ACID MONOPOTASSIUM SALT Phenyl chlorothionocarbonate Thioacetamide BRL 6231 WRW4 Potassium phthalimide

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