|
| | Sevelamer carbonate Basic information |
| Product Name: | Sevelamer carbonate | | Synonyms: | 2-Propen-1-amine polymer with (chloromethyl)oxirane carbonate;Sevelamer carbonate;Carbonic acid, compd. with 2-(chloromethyl)oxirane polymer with 2-propen-1-amine;Sevelam;2-Propen-1-amine polymer with (chloromethyl)oxiran;2-Propen-1-aminepolymerwith;carbonic acid,2-(chloromethyl)oxirane,prop-2-en-1-amine;SIM862 Sevelamer Carbonate-----25gm | | CAS: | 845273-93-0 | | MF: | C7H14ClNO4 | | MW: | 211.64 | | EINECS: | 682-521-9 | | Product Categories: | Inhibitors;Pharmaceutical intermediate;Other APIs | | Mol File: | 845273-93-0.mol |  |
| | Sevelamer carbonate Chemical Properties |
| storage temp. | Room Temperature, under inert atmosphere | | solubility | <4.74mg/mL in DMSO | | form | Solid | | color | White to Pale Beige |
| | Sevelamer carbonate Usage And Synthesis |
| Description | Sevelamer carbonate (SC) is a non-absorbed phosphate binding crosslinked polymer, with the same polymeric structure as sevelamer hydrochloride, in which carbonate replaces chloride as the counterion. SC has been found to have the same safety and efficacy profile as Sevelamer HCl in HD patients.
Sevelamer carbonate(Renvela) is a nonaluminum, non-calcium-basedphosphorus binder that traps phosphorus in the bowel through ion exchange and hydrogen binding. This drug replaced sevelamer hydrochloride(Renagel) and has an advantage of not generating an acid load, as its precursor, sevelamer hydrochloride, did. It also has the advantage of lowering LDL cholesterol due to gut binding of bile acids. | | Uses | Sevelamer Carbonate, a non-?absorbed polymer is an oral phosphate binder in patients with kidney failure. It is reported that Sevelamer Carbonate is less likely to cause hypercalcemia, low levels of PTH, and progressive coronary and aortic calcification in hemodialysis patients than calcium-?based phosphate binders. | | Uses | Control of serum phosphorus in patients with chronic kidney disease (phosphate binder). |
| | Sevelamer carbonate Preparation Products And Raw materials |
|
