Boc-8-aoc-oh can be used as a PROTAC linker in the synthesis of PROTACs. Boc-8-aoc-oh is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
Chemical Properties
White amorphous powder
Uses
Reagent to introduce a protected w-amino alkyl spacer. Longer spacer arms often impart increased activity to the substrate
BOC-8-AMINOCAPRYLIC ACID Preparation Products And Raw materials
