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| 1-Isoquinolinecarbonitrile Basic information |
| 1-Isoquinolinecarbonitrile Chemical Properties |
Melting point | 90-92 °C (lit.) | Boiling point | 348.9±15.0 °C(Predicted) | density | 1.21±0.1 g/cm3(Predicted) | storage temp. | Sealed in dry,Room Temperature | pka | -0.48±0.30(Predicted) | Water Solubility | Insoluble in water. | BRN | 119104 | CAS DataBase Reference | 1198-30-7(CAS DataBase Reference) |
Hazard Codes | Xn,Xi | Risk Statements | 20/21/22-36/37/38 | Safety Statements | 26-37/39 | RIDADR | 3276 | WGK Germany | 3 | Hazard Note | Irritant | HazardClass | 6.1 | PackingGroup | III | HS Code | 2933499090 |
| 1-Isoquinolinecarbonitrile Usage And Synthesis |
Uses | 1-Isoquinolinecarbonitrile may be used as starting reagent in the syntheses of imidazo[5,1-a]isoquinolines. | Preparation | Phosphoryl chloride (0.54 g, 3.5 mmol) in chloroform (5 mL) was added dropwise to a solution of the requisite carbaldoxime (0.2 g, 1.2 mmol) in chloroform (10 mL) under ice-cooling. The mixture was heated under reflux for 4 h, treated with iced water, and the resulting precipitate was filtered off. The filtrate was basified with 28% ammonia and then extracted with chloroform to give 1-cyanoisoquinoline 1440; yield 0.17 g (95%). | Synthesis Reference(s) | The Journal of Organic Chemistry, 49, p. 4056, 1984 DOI: 10.1021/jo00195a036 Tetrahedron Letters, 19, p. 589, 1978 | General Description | Effect of magnetic field on the photosubstitution reaction of 1-isoquinolinecarbonitrile in ethanol has been reported. Conjugated polynitrile, plasma-polymerized 1-isoquinolinecarbonitrile (PPIQCN) has been prepared by plasma polymerization. |
| 1-Isoquinolinecarbonitrile Preparation Products And Raw materials |
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1,2,3,4-TETRAHYDRO-ISOQUINOLIN-7-YLAMINE HCL
1-METHYLISOQUINOLINE
2-BENZOYL-1,2,3,4-TETRAHYDRO-1-ISOQUINOLINECARBONITRILE
1-Isoquinolinecarbonitrile
2-benzoyl-3-methyl-1,2-dihydro-1-isoquinolinecarbonitrile
1-Isoquinolinecarbonitrile,5-amino-(9CI)
1-PIPERAZIN-1-YL-ISOQUINOLIN-3-YLAMINE
1-(4-METHYLPHENYL)-3-[(3,4,4-TRIFLUORO-3-BUTENYL)SULFANYL]-5,6,7,8-TETRAHYDRO-4-ISOQUINOLINECARBONITRILE
2-Acetyl-1,2-dihydro-1-isoquinolinecarbonitrile
3-([4-(TERT-BUTYL)BENZYL]SULFANYL)-1-PHENYL-5,6,7,8-TETRAHYDRO-4-ISOQUINOLINECARBONITRILE
5-(4-methylphenyl)-1,2,3,4-tetrahydropyrimido[4',5':4,5]thieno[2,3-c]isoquinolin-8-ylamine
1-(4-fluorophenyl)-3-{[2-(4-methoxyphenyl)-2-oxoethyl]sulfanyl}-5,6,7,8-tetrahydro-4-isoquinolinecarbonitrile
6-BROMO-ISOQUINOLIN-1-YLAMINE
2-Cyanopyridine
3-[(3-FLUOROBENZYL)SULFANYL]-1-(3-METHYLPHENYL)-5,6,7,8-TETRAHYDRO-4-ISOQUINOLINECARBONITRILE
3-THIOXO-1-(3,4,5-TRIMETHOXY-PH)2,3,5,6,7,8-HEXAHYDRO-4-ISOQUINOLINECARBONITRILE
5-CYANOISOQUINOLINE
3-Isoquinolinecarbonitrile
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