(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE

(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE Basic information

Product Name:	(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE
Synonyms:	(+)-ALPHA-METHOXY-ALPHA-(TRIFLUOROMETHYL)PHENYLACETYL CHLORIDE;(S)-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl chloride, 98+%;(S)-(+)-MTPA-Cl, Moshers acid chloride;(S)-(+)-^a-Methoxy-^a-(trifluoromethyl)phenylacetyl chloride, 98+%;(S)-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl chloride,99%;(R)-(-)-A-METHOXY-A-(TRIFLUOROMETHYL)PHENYLACETYL CHLORIDE;(R)-(-)-ALPHA-METHOXY-ALPHA-(TRIFLUOROMETHYL)BENZENEACETYLCHLORIDE;R(-)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETIC ACID CHLORIDE
CAS:	20445-33-4
MF:	C10H8ClF3O2
MW:	252.62
EINECS:	633-847-5
Product Categories:	Analytical Chemistry;e.e. / Absolute Configuration Determination (NMR);Enantiomer Excess & Absolute Configuration Determination
Mol File:	20445-33-4.mol

(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE Chemical Properties

Boiling point	213-214 °C(lit.)
alpha	D24 +129.0± 0.2° (c = 5.17 in CCl4)
density	1.35 g/mL at 25 °C(lit.)
refractive index	n20/D 1.47(lit.)
Fp	194 °F
storage temp.	-20°C
form	Liquid
Specific Gravity	1.353
color	Clear colorless to light yellow
optical activity	[α]20/D +137±2°, c = 6.4% in carbon tetrachloride
Water Solubility	Slightly miscible with water.
Sensitive	Moisture Sensitive
Merck	14,6280
BRN	3591564
CAS DataBase Reference	20445-33-4(CAS DataBase Reference)

Safety Information

MSDS Information

(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE Usage And Synthesis

Chemical Properties	clear colorless to light yellow liquid
Uses	Resolution of enantiomers primarily of alcohols and amines.
Uses	(S)-(+)-α-Methoxy-α-(trifluoromethyl)phenylacetyl chloride is used in the preparation of natural products and pheromones. It is also employed as a derivatization enantiomeric purity reagent used for the determination of enantiomeric purity of alcohol and amines by gas chromatography.
Uses	Used in the synthesis of natural products and pheromones.
General Description	(S)-(+)-α-Methoxy-α-trifluoromethylphenylacetyl chloride is commonly used as a derivatizing agent in Mosher ester analysis and Mosher amide analysis, which are NMR-based methods for determining the absolute configuration of the chiral carbon center in secondary alcohols and amines, respectively.
Purification Methods	The most likely impurity is the free acid due to hydrolysis and should be checked by IR. If free from acid, then distil, taking care to keep moisture out of the apparatus. Otherwise add SOCl2 and reflux for 5hours and distil it. Note that shorter reflux times result in a higher boiling fraction (b 130-155o/1mm) which has been identified as the anhydride. [Dale et al. J Org Chem 34 2543 1969, for enantiomeric purity see Dale & Mosher J Am Chem Soc 97 512 1973.]

(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE Preparation Products And Raw materials

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