3,4-Dimethoxy-3-cyclobutene-1,2-dione

3,4-Dimethoxy-3-cyclobutene-1,2-dione Basic information
Product Name:3,4-Dimethoxy-3-cyclobutene-1,2-dione
Synonyms:3-Cyclobutene-1,2-dione,3,4-dimethoxy-;3,4-Dimethoxycyclobut-3-ene-1,2-dione 98%;Dimethyl squarate, 1,2-Dimethoxy-3,4-dioxocyclobut-1-ene;Dimethyl squarate 3,4-Dimethoxy-3-cyclobutene-1,2-dione;SQUARIC ACID DIMETHYL ESTER;3,4-DIMETHOXY-3-CYCLOBUTENE-1,2-DIONE;Squaric acid dimethyl ester,(Dimethyl squarate, 3,4-Dimethoxy-3-cyclobutene-1,2-dione);3,4-DIMETHOXYCYCLOBUTANE-1,2-DIONE
CAS:5222-73-1
MF:C6H6O4
MW:142.11
EINECS:627-380-6
Product Categories:Cyclobutanes & Cyclobutenes;Simple 4-Membered Ring Compounds;Ring Systems;Aluminium foil bag/Fluoride bottle or on your request;Pyrimidines
Mol File:5222-73-1.mol
3,4-Dimethoxy-3-cyclobutene-1,2-dione Structure
3,4-Dimethoxy-3-cyclobutene-1,2-dione Chemical Properties
Melting point 55-57 °C (lit.)
Boiling point 219.65°C (rough estimate)
density 1.3863 (rough estimate)
refractive index 1.5800 (estimate)
storage temp. 2-8°C
solubility DMSO, Methanol (Slightly)
form Solid
color Off-White to Pale Brown
Water Solubility Very soluble in water.
InChIKeySZBNZTGCAMLMJY-UHFFFAOYSA-N
CAS DataBase Reference5222-73-1(CAS DataBase Reference)
NIST Chemistry Reference3,4-Dimethoxy-3-cyclobutene-1,2-dione(5222-73-1)
Safety Information
Risk Statements 42/43
Safety Statements 22-24/25-26-36/37/39
WGK Germany 3
HS Code 29145090
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
ALFA English
3,4-Dimethoxy-3-cyclobutene-1,2-dione Usage And Synthesis
Chemical Propertieswhite crystalline powder
Uses3,4-Dimethoxy-3-cyclobutene-1,2-dione (Dimethyl squarate) finds it uses in the synthesis of chiral squaramides, highly enantioselective catalyst for the Friedel-Crafts reactions of indoles, 3-(hydroxyamino)-4-methoxy-3-cyclobutene-1,2-dione, squarate derivatives of the O-SP-core antigens, methyl squarate derivative of the Ogawa O-SP-core antigen, o-quinodimethanes, benzocyclobutenes, quinones. It is employed as a starting material in the preparation of o-quinodimethanes, benzocyclobutenes, and quinones.
General Description3,4-Dimethoxy-3-cyclobutene-1,2-dione (Dimethyl squarate) is a cyclobutene derivative. It reacts with hydroxylamine derivatives to afford 3-hydroxyamino-4-methoxy-3-cyclobutene-1,2-diones.
3,4-Diisopropoxy-3-cyclobutene-1,2-dione Diethyl squarate Dacthal Dimethyl malate Dimethyl acetylenedicarboxylate 1,2-Cyclobutanedione 3-cyclobutene-1,2-dione 3,4-Dimethoxy-3-cyclobutene-1,2-dione Dimethyl suberate Dimethyl malonate 3-SULFOLENE Dibutyl squarate S,S'-Dimethyl dithiocarbonate DIMETHYL PHOSPHATE Squaric acid 1,1-Dimethoxyethane Dimethyl sebacate Dimethyl ether

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