ChemicalBook Product Catalog Chemical Reagents Organic reagents fatty acid (S)-(-)-2-Chloropropionic acid

(S)-(-)-2-Chloropropionic acid

(S)-(-)-2-Chloropropionic acid Basic information
Product Name:(S)-(-)-2-Chloropropionic acid
Synonyms:PROPANOIC ACID, 2-CHLORO-, (2S)-;(S)-(-)-2-CHLOROPROPIONIC ACID;(S)-2-CHLOROPROPIONIC ACID;(S)-(-)-2-CHLOROPROPIONOIC ACID;(S)-(-)-2-CHLOROPROPANOIC ACID;(2s)-chloropropanoicacid;L-α-Chloropropionic acid;L-(-)-2-Chloro Proxic Acid
CAS:29617-66-1
MF:C3H5ClO2
MW:108.52
EINECS:411-150-5
Product Categories:Heterocycle-Pyridine series;Miscellaneous Reagents;Building Blocks for Liquid Crystals;Carboxylic Acids (Chiral);Chiral Building Blocks;Chiral Compounds (Building Blocks for Liquid Crystals);Chiral Compounds;chiral;Functional Materials;Synthetic Organic Chemistry;29617-66-1
Mol File:29617-66-1.mol
(S)-(-)-2-Chloropropionic acid Structure
(S)-(-)-2-Chloropropionic acid Chemical Properties
Melting point 4 °C
alpha -14.5 º (c=neat)
Boiling point 77 °C/10 mmHg (lit.)
density 1.249 g/mL at 25 °C (lit.)
vapor pressure 5hPa at 20℃
refractive index n20/D 1.436
Fp 140 °F
storage temp. 2-8°C
solubility DMSO (Slightly), Methanol (Slightly), Water (Slightly)
pka2.83(at 25℃)
form Liquid
color Clear light yellow
Water Solubility soluble
BRN 1720257
LogP0.82 at 20.5℃
CAS DataBase Reference29617-66-1(CAS DataBase Reference)
NIST Chemistry Reference(S)-(-)-2-chloropropionic acid(29617-66-1)
Safety Information
Hazard Codes C
Risk Statements 21/22-35-48/22
Safety Statements 23-26-28-36/37/39-45
RIDADR UN 2511 8/PG 3
WGK Germany 1
RTECS UA2451950
HazardClass 8
PackingGroup III
HS Code 29159080
MSDS Information
ProviderLanguage
2-Chloropropanoic acid English
SigmaAldrich English
ACROS English
ALFA English
(S)-(-)-2-Chloropropionic acid Usage And Synthesis
Chemical PropertiesColourless Oil
UsesThrough the stereo displacement of (S)-(-)-2-Chloropropionic acid PPAR Agonist can be synthesized via asymmetric hydrogenation of a cinnamic acid derivative.
DefinitionChEBI: A monocarboxylic acid that is propanoic acid substitued at position 2 by a chloro group (the S-enantiomer).
Flammability and ExplosibilityNonflammable
Purification MethodsPurify the acid by fractionating twice through a 115cm Podbielniak column (p 11, calculated 50 theoretical plates at atmospheric pressure) using a take-off ratio of 1:5. The acid chloride is prepared by dissolving the acid in SOCl2, adding a few drops of PCl3, refluxing and then distilling through a 30cm column, b 53o/100mm, [] -4.6o (neat), d 1.2689, n1.4368. [Fu et al. J Am Chem Soc 76 6954 1954, Beilstein 2 IV 745.]
(S)-(-)-2-Chloropropionic acid Preparation Products And Raw materials
Raw materialsPropanal, 2-chloro-, (2R)- (9CI)-->(R)-(+)-2-Chloropropionic acid-->Methyl 2-chloropropionate
Preparation Products(R)-(+)-2-BENZYLOXYPROPIONIC ACID
DALAPON-METHYL ESTER A,A-DICHLOROSUCCINIC ACID (MESO) (S)-2-Chloropropionic acid methyl (S)-2-CHLORO-4-METHYL-N-VALERIC ACID (S)-(-)-2-Chloropropionic acid DIISOPROPYL CHLOROMALONATE (S)-2-CHLORO-3-METHYLBUTYRIC ACID DIETHYL ETHYLCHLOROMALONATE ALPHA-CHLORO-3,5,7-TRIMETHYL-1-ADAMANTANEACETIC ACID (S)-2-CHLOROSUCCINIC ACID (2S,3S)-2-CHLORO-3-METHYL-N-VALERIC ACID Diethyl chloromalonate (S)-2-CHLORO-N-BUTYRIC ACID Dimethyl chloromalonate (S)-2-CHLOROPROPIONIC ACID LSOBUTYL ESTER,(S)-2-Chloropropionic acid 2-methylpropyl ester phosphoric acid (S)-(-)-2-CHLOROPENTANOIC ACID 2,2-DICHLOROPROPIONIC ACID SODIUM SALT
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