2-Biphenylcarboxylic acid

2-Biphenylcarboxylic acid Basic information

Product Name:	2-Biphenylcarboxylic acid
Synonyms:	O-PHENYLBENZOIC ACID;TIMTEC-BB SBB007790;RARECHEM AL BE 0859;[1,1’-Biphenyl]-2-carboxylicacid;Biphenylcarboxylic acid-(2);DIPHENYL-2-CARBOXYLIC ACID;LABOTEST-BB LT00452563;2-BIPHENYLCARBOXYLIC ACID
CAS:	947-84-2
MF:	C13H10O2
MW:	198.22
EINECS:	213-432-1
Product Categories:	Biphenyl series;Biphenyl derivatives;Organic acids;Benzene derivatives
Mol File:	947-84-2.mol

2-Biphenylcarboxylic acid Chemical Properties

Melting point	111-113 °C(lit.)
Boiling point	199 °C10 mm Hg(lit.)
density	1.1184 (rough estimate)
refractive index	1.5954 (estimate)
Fp	343-344°C
storage temp.	Sealed in dry,Room Temperature
pka	3.46(at 25℃)
form	Crystalline Powder
color	White to beige
Water Solubility	insoluble
BRN	974075
InChIKey	ILYSAKHOYBPSPC-UHFFFAOYSA-N
CAS DataBase Reference	947-84-2(CAS DataBase Reference)
NIST Chemistry Reference	2-Biphenylcarboxylic acid(947-84-2)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36-37/39-37
WGK Germany	3
HazardClass	IRRITANT
HS Code	29163900

MSDS Information

Provider	Language
2-Phenylbenzoic acid	English
SigmaAldrich	English
ACROS	English
ALFA	English

2-Biphenylcarboxylic acid Usage And Synthesis

Chemical Properties	2-Biphenylcarboxylic acid is White powder
Uses	2-Biphenylcarboxylic acid is used in the preparation of neuropeptide FF receptor antagonists. In addition it is used in the synthesis of disubstituted piperidines as orexin receptor antagonists.
Uses	It is used as a pharmaceutical intermediate. he reaction of 2?-substituted biphenyl-2-carboxylic acids (where the 2?-substituent is H, CO2H, NO2, Cl, OMe, or CO2Me) with lead tetra-acetate in refluxing benzene solution, under a nitrogen atmosphere, affords 3,4-benzocoumarin as a major organic product.
Synthesis Reference(s)	The Journal of Organic Chemistry, 43, p. 447, 1978 DOI: 10.1021/jo00397a015
Purification Methods	Crystallise the acid from *C6H6/pet ether or aqueous EtOH. [Beilstein 9 IV 2472.]

2-Biphenylcarboxylic acid Preparation Products And Raw materials

Raw materials	METHYL BIPHENYL-2-CARBOXYLATE-->Tetraphenyltin-->Phenyltrimethoxysilane-->Sodium tetraphenylboron-->Phenylboronic acid-->CARBON DIOXIDE-->Methanesulfonic acid, 1,1,1-trifluoro-, [1,1'-biphenyl]-2-yl ester
Preparation Products	Bifenthrin-->2-PHENYLBENZYLAMINE HYDROCHLORIDE-->[1,1':3',1'']TERPHENYL-2'-CARBOXYLIC ACID-->2-Iodobiphenyl-->6H-dibenzo-(b,d)-pyran-6-one-->1-broMo-9h-fluoren-9-one

2'-Nitro-4-biphenylcarboxylic acid 4'-(Heptyloxy)-4-biphenylcarboxylic acid p-(2-methylbutyl)phenyl ester 4-(Heptyloxy)-4'-biphenylcarboxylic acid 4-Biphenylcarboxylic acid ethyl ester 2-Fluorobiphenyl-4-carboxylic Acid Ethyl 2-(Chlorosulfonyl)acetate Phenylacetone 4-Heptyl-4'-biphenylcarboxylic acid 9H-FLUORENE-4-CARBOXYLIC ACID 7-NITRO-9-OXO-4-FLUORENECARBOXYLIC ACID METHYL 2-BROMO-7-NITRO-9-FLUORENONE-4-CARBOXYLATE Diphenic acid Diphenic anhydride 4'',4''''''-Azobis-(4-biphenylcarboxylic acid) 1-Phenyl-2-nitropropene 2',4'-Difluoro-4,5-dihydroxy-3-biphenylcarboxylic acid phosphoric acid 2-AMINO-6 H-DIBENZO[B,D]PYRAN-6-ONE

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