|
| | Methanesulfonamide Basic information |
| | Methanesulfonamide Chemical Properties |
| Melting point | 85-89 °C(lit.) | | Boiling point | 208.2±23.0 °C(Predicted) | | density | 1.229 (estimate) | | refractive index | 1.5130 (estimate) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | Slightly soluble in DMSO and methanol. | | form | Crystals, Powder or Flakes | | pka | 10.87±0.60(Predicted) | | color | White to yellow | | BRN | 1740835 | | InChIKey | HNQIVZYLYMDVSB-UHFFFAOYSA-N | | CAS DataBase Reference | 3144-09-0(CAS DataBase Reference) | | NIST Chemistry Reference | Methane sulfonamide(3144-09-0) | | EPA Substance Registry System | Methanesulfonamide (3144-09-0) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36-24/25 | | WGK Germany | 3 | | TSCA | T | | HazardClass | IRRITANT | | HS Code | 29350090 |
| | Methanesulfonamide Usage And Synthesis |
| Chemical Properties | White to yellow crystals, powder or flakes | | Uses | - Methanesulfonamide is used in the synthesis of important organic reagents such as N-(2-methylthio-1-p-toluenesufonyl)methanesulfonamide and tert-butyl ((2-(trimethylsilyl)ethyl)sulfonyl)carbamate.
- It can be used as a source of nitrogen in the conversion of carboxylic acids to corresponding nitriles.
- It is widely used as a reagent in the synthesis of medicinally important compounds such as derivatives of indole-N-acetamide, methanesulfonamide pyrimidine-substituted 3,5-dihydroxy-6-heptenoates and repertaxin.
| | Uses | Methanesulfonamide will react with thionyl chloride, cyanates, carbon disulfide and ketones and aldehydes to prepare pharmaceuticals, brightening agent and other target molecules. It is also used in biological studies to predict binding affinity and binding mode of protein ligand complexes. | | Synthesis Reference(s) | Journal of the American Chemical Society, 90, p. 4096, 1968 DOI: 10.1021/ja01017a032
The Journal of Organic Chemistry, 60, p. 7682, 1995 DOI: 10.1021/jo00128a048
Tetrahedron Letters, 35, p. 7201, 1994 DOI: 10.1016/0040-4039(94)85360-6 |
| | Methanesulfonamide Preparation Products And Raw materials |
|
