|
| | Propacetamol Basic information |
| Product Name: | Propacetamol | | Synonyms: | PROPACETAMOL;4-Acetamidophenyl diethylaminoacetate hydrochloride;Pro-Dafalgan;N，N-Diethylglycine 4-(acetylamino)phenyl ester;(Diethylamino)acetic acid 4-(acetylamino)phenyl;4-Acetamidophenyl N,N-diethylglycinate;4-acetamidophenyl N,N-diethylaminoacetate;Glycine, N,N-diethyl-, 4-(acetylamino)phenyl ester | | CAS: | 66532-85-2 | | MF: | C14H20N2O3 | | MW: | 264.32 | | EINECS: | 266-390-1 | | Product Categories: | | | Mol File: | 66532-85-2.mol |  |
| | Propacetamol Chemical Properties |
| Melting point | 55-57 °C | | Boiling point | 434.5±30.0 °C(Predicted) | | density | 1.132±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | H2O : 100 mg/mL (378.33 mM; Need ultrasonic) | | pka | 14.20±0.70(Predicted) | | CAS DataBase Reference | 66532-85-2(CAS DataBase Reference) |
| | Propacetamol Usage And Synthesis |
| Description | Propacetamol is the prodrug of paracetamol (acetaminophen),
used for intravenous administration. It
results from eombination of paracetamol and diethylglycine.
Causes contact dermatitis and airborne dermatitis
in nurses. Allergenic properties are due to the
N,N' -diethylglycine moiety, and not to the paracetamol
moiety. | | Uses | Propacetamol hydrochloride is a water-soluble prodrug for intravenous administration resulting in the liberation of paracetamol. | | Definition | ChEBI: Propacetamol is an alpha-amino acid ester. | | Contact allergens | Propacetamol is a prodrug of paracetamol (acetaminophen)
used for intravenous administration. It results
from the combination of paracetamol and diethylglycine.
It caused contact (hand and airborne) dermatitis in
nurses and acute systemic dermatitis (pompholyx and
nummular dermatitis, generalized eczema, urticaria-like
eruption) in nurses who had became sick and received
intravenous propacetamol. Allergenic properties are due
to the N,N-diethylglycine moiety, and not to the paracetamol
moiety. Propacetamol is now substituted by a
solution of paracetamol in mannitol (Perfalgan?). |
| | Propacetamol Preparation Products And Raw materials |
|
