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| | Difluoroacetic acid Basic information |
| | Difluoroacetic acid Chemical Properties |
| Melting point | -1 °C (lit.) | | Boiling point | 132-134 °C (lit.) | | density | 1.526 g/mL at 25 °C (lit.) | | vapor pressure | 11.7hPa at 25℃ | | refractive index | n20/D 1.344(lit.) | | Fp | 174 °F | | storage temp. | 2-8°C | | solubility | 540.54g/L in organic solvents at 20 ℃ | | form | Liquid | | pka | pK1:1.33 (25°C) | | Specific Gravity | 1.527 (20℃) | | color | Clear colorless to light brown | | Water Solubility | 1000g/L at 37℃ | | BRN | 1098588 | | InChIKey | PBWZKZYHONABLN-UHFFFAOYSA-N | | LogP | 0.601 at 37℃ | | CAS DataBase Reference | 381-73-7(CAS DataBase Reference) | | NIST Chemistry Reference | Difluoroacetic acid(381-73-7) | | EPA Substance Registry System | Acetic acid, difluoro- (381-73-7) |
| Hazard Codes | C | | Risk Statements | 34-35 | | Safety Statements | 26-36/37/39-45 | | RIDADR | UN 3265 8/PG 2 | | WGK Germany | 3 | | RTECS | AG9900000 | | Hazard Note | Corrosive | | TSCA | T | | HazardClass | 8 | | PackingGroup | II | | HS Code | 29159080 |
| | Difluoroacetic acid Usage And Synthesis |
| Chemical Properties | clear colorless to light brown liquid | | Uses | Used in the preparation of 2-difluoromethylbenzimidazoles, -oxazoles and -thiazoles from ortho-substituted anilines mediated by triphenylphoshine. | | Definition | ChEBI: A monocarboxylic acid that is acetic acid in which two of the methyl hydrogens are substituted by fluorines. | | Flammability and Explosibility | Nonflammable | | Purification Methods | Purify the acid by distilling over P2O5. The acid chloride is a fuming liquid b 25o/atm, and the amide has b 108.6o/35mm, m 52o (from *C6H6), and the anilide has b 90o/1mm, 114o/5mm, m 58o [Henne & Pelley J Am Chem Soc 74 1426 1952, Coffman et al. J Org Chem 14 749 1949, NMR: Meyer et al. J Am Chem Soc 75 4567 1953, pK: Wegscheider Z Phys Chem 69 614 1909]. [Beilstein 2 IV 455.] |
| | Difluoroacetic acid Preparation Products And Raw materials |
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