BRL 54443

BRL 54443 Basic information
Product Name:BRL 54443
Synonyms:BRL 54443;5-HYDROXY-3-(1-METHYLPIPERIDIN-4-YL)-1H-INDOLE;3-(1-Methyl-4-piperidinyl)-1H-indol-5-ol;3-(1-Methyl-4-piperidinyl)-1H-indol-5-ol BRL 54443;3-(1-methylpiperidin-4-yl)-1H-indol-5-ol;1H-Indol-5-ol, 3-(1-Methyl-4-piperidinyl)-;BRL 54443 HCl;BRL-54443;BRL54443
CAS:57477-39-1
MF:C14H18N2O
MW:230.31
EINECS:
Product Categories:Inhibitors
Mol File:Mol File
BRL 54443 Structure
BRL 54443 Chemical Properties
Boiling point 431.5±45.0 °C(Predicted)
density 1.196
storage temp. Inert atmosphere,2-8°C
solubility H2O: 50 mg/mL
form solid
pka10.08±0.40(Predicted)
color white
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 3
MSDS Information
BRL 54443 Usage And Synthesis
UsesBRL-53443 is a potent 5-HT and dopamine receptor agonist. Neuroresearch product.
DefinitionChEBI: 3-(1-methyl-4-piperidinyl)-1H-indol-5-ol is a member of hydroxyindoles.
Biological ActivityA potent 5-ht 1E/1F receptor agonist (pEC 50 values are 8.5 and 8.6 respectively). Displays > 30-fold selectivity over other 5-HT and dopamine receptors (pK i values are 8.7. 8.9, 7.2, 6.9, 7.2, 5.9, 7.0, 6.5, < 6, < 6, 6.3 and 6.2 for human 5-HT 1E , 1F , 1A , 1B , 1D , 2A , 2B , 2C , 4 , 7 , D 2 and D 3 receptors respectively). Induces 5-HT 2A receptor-mediated mouse aortic contraction in vitro (pEC 50 = 6.52). Active in vivo .
storage+4°C (desiccate)
references1. a.m. brown, k. avenell, t j. young et al. brl 54443, a potent agonist with selectivity for human cloned 5-ht1e and 5-ht1f receptors. 1998. br.j.pharmacol. 123 233p.2. s. lightowler, t. stean, n. upton et al. effect of brl 54443 (3-(1-methylpiperidin-4-yl)-1h-indol-5-ol), a 5-ht1e/1f receptor agonist, on general behaviour and maximal electroshock seizure threshold in the rat. 1998. br.j.pharmacol. 123 237p.3. mckune cm, watts sw. characterization of the serotonin receptor mediating contraction in the mouse thoracic aorta and signal pathway coupling. j pharmacol exp ther. 2001 apr;297(1):88-95.4. janssen p, tack j, sifrim d et al. influence of 5-ht1 receptor agonists on feline stomach relaxation. eur j pharmacol. 2004 may 25;492(2-3):259-67.
BRL 54443 Preparation Products And Raw materials
PLX4032 Dacomitinib Erlotinib hydrochloride Pomalidomide Lenalidomide Panobinostat 3-Methylpiperidin-3-ol HCl Hexamidine piperidine

Email:[email protected] [email protected]
Copyright © 2025 Mywellwork.com All rights reserved.