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| | TOS-ARG-OME HCL Basic information |
| | TOS-ARG-OME HCL Chemical Properties |
| Melting point | 145-147(lit.) | | alpha | -14 º (c=4, H2O) | | refractive index | -14 ° (C=4, H2O) | | storage temp. | -20°C | | solubility | methanol: 50 mg/mL, clear, colorless | | form | Fine Crystalline Powder | | color | White | | BRN | 3922357 | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months. | | InChIKey | JIQFFACVQXXHMY-YDALLXLXSA-N | | CAS DataBase Reference | 1784-03-8(CAS DataBase Reference) |
| | TOS-ARG-OME HCL Usage And Synthesis |
| Description | TAME (1784-03-8) binds to the ubiquitin ligase anaphase-promoting complex (APC) preventing its activation by Cdc20 and Cdh1 and resulting in mitotic arrest.1,2 | | Chemical Properties | white fine crystalline powder | | Uses | enzyme inhibitor | | Uses | Substrate for trypsin, thrombin, plasmin and other proteases. | | Uses | N-4-Tosyl-L-arginine Methyl Ester Hydrochloride acts as a synthetic substrate of serine proteases and thus is used to determine serine proteases from diverse organic sources. | | Biochem/physiol Actions | Nα-p-Tosyl-L-arginine methyl ester (TAME) binds to anaphase-promoting complex (APC) and prevents its activation by Cdc20 and Cdh1. | | References | 1) Zeng et al. (2010) Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage; Cancer Cell, 18 382
2) Zeng and King (2012) An APC/C inhibitor stabilizes Cyclin B1 by prematurely terminating ubiquitination; Nat. Chem. Biol., 8 383 |
| | TOS-ARG-OME HCL Preparation Products And Raw materials |
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