ChemicalBook Product Catalog Chemical Reagents Organic reagents Aromatics Ethyl 3-(4-fluorophenyl)-3-oxopropanoate

Ethyl 3-(4-fluorophenyl)-3-oxopropanoate

Ethyl 3-(4-fluorophenyl)-3-oxopropanoate Basic information
Product Name:Ethyl 3-(4-fluorophenyl)-3-oxopropanoate
Synonyms:(4-FLUOROBENZOYL)ACETIC ACID ETHYL ESTER;3-(4'-Fluorophenyl)-3-oxopropanoate;ETHYL 3-(4'-FLUOROPHENYL)-3-OXOPROPNOATE;ETHYL 4-FLUOROBENZOYLACETATE;ETHYL (P-FLUOROBENZOYL)ACETATE;3-(4-FLUORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER;3-Oxo-3-(4-fluorophenyl)propanoic acid ethyl ester;p-Fluorobenzoylacetic acid ethyl ester
CAS:1999-00-4
MF:C11H11FO3
MW:210.2
EINECS:
Product Categories:Benzene series;Benzoic acid;Acids & Esters;Fluorine Compounds
Mol File:1999-00-4.mol
Ethyl 3-(4-fluorophenyl)-3-oxopropanoate Structure
Ethyl 3-(4-fluorophenyl)-3-oxopropanoate Chemical Properties
Melting point 117-120℃
Boiling point 117-120 °C(lit.)
density 1.174 g/mL at 25 °C(lit.)
refractive index n20/D 1.5040(lit.)
Fp >230 °F
storage temp. Keep in dark place,Sealed in dry,Room Temperature
pka9.82±0.25(Predicted)
form clear liquid
color Colorless to Almost colorless
Specific Gravity1.19
InChIKeySJUXLKYJKQBZLM-UHFFFAOYSA-N
CAS DataBase Reference1999-00-4(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Safety Statements 24/25
WGK Germany 3
Hazard Note Irritant
HS Code 29183000
MSDS Information
ProviderLanguage
SigmaAldrich English
Ethyl 3-(4-fluorophenyl)-3-oxopropanoate Usage And Synthesis
Chemical PropertiesColorless liquid
UsesReactant used as a precursor in:
  • Condensation reactions with diamines via C-C bond cleavage for synthesis of benzimidazoles and perimidines for possible use as antimalarial treatments
  • Base-promoted domino Michael addition / cyclization / elimination reactions for synthesis of hydroxybenzophenones
  • Oxidative cross-coupling with indoles via dioxygen activation
  • Cyclization of keto esters for synthesis of pyrones
  • Lewis base catalyzed hydrosilylation for synthesis of α-acetoxy β-amino acid derivatives
  • Conia-ene reactions for synthesis of methylenecyclopentane derivatives
General DescriptionEthyl (4-fluorobenzoyl)acetate on condensation with benzofurazan oxide yields 2-(carboethoxy)-3-(4′-fluoro)phenylquinoxaline1,4-dioxide.
Ethyl 3-(4-fluorophenyl)-3-oxopropanoate Preparation Products And Raw materials
Preparation Products2-Amino-6-(4-fluorophenyl)pyrimidin-4(3H)-one-->3-Benzofurancarboxylic acid, 2-(4-fluorophenyl)-5-(1-Methylethoxy)-, ethyl ester-->6-(4-FLUOROPHENYL)-2-METHYLPYRIMIDIN-4-OL(WXG00143)-->(4-FLUORO-PHENYL)-PROPYNOIC ACID ETHYL ESTER-->ethyl 5-bromo-2-(4-fluorophenyl)benzofuran-3-carboxylate
Ethyl propionylacetate ETHYL 7-FLUORO-1-(4-METHYLBENZYL)-4-OXO-1,4-DIHYDRO-3-QUINOLINECARBOXYLATE Ethyl 3-bromo-2,4,5-trifluorobenzoylacetate PHENOXYACETIC ACID AKOS 90579 ETHYL 3-(3-FLUOROPHENYL)-3-OXOPROPANOATE Ethyl 2,3,4,5-tetrafluorobenzoyl acetate ETHYL 1-ALLYL-7-FLUORO-4-OXO-1,4-DIHYDRO-3-QUINOLINECARBOXYLATE Ethyl 3-(4-fluorophenyl)-3-oxopropanoate 3-(3,4-DIFLUOROPHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER Ethyl 2,4,5-trifluorobenzoylacetate Dibenzoyltartaric acid Ethyl (pentafluorobenzoyl)acetate ISOXADIFEN-ETHYL Dibenzoylmethane Calcium folinate ETHYL 3-(2-FLUOROPHENYL)-3-OXOPROPANOATE Ethyl malonyl chloride
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