2,5-Dimethoxycinnamic acid

2,5-Dimethoxycinnamic acid Basic information
Product Name:2,5-Dimethoxycinnamic acid
Synonyms:3-(2,5-DIMETHOXYPHENYL)-2-PROPENOIC ACID;2,5-DIMETHOXYCINNAMIC ACID;AKOS BBS-00007757;OTAVA-BB BB0109770774;RARECHEM BK HC T324;TIMTEC-BB SBB000471;TRANS-2,5-DIMETHOXYCINNAMIC ACID;(2E)-3-(2,5-dimethoxyphenyl)prop-2-enoic acid
CAS:10538-51-9
MF:C11H12O4
MW:208.21
EINECS:234-114-9
Product Categories:Acids & Esters;Anisoles, Alkyloxy Compounds & Phenylacetates;C11 to C12;Carbonyl Compounds;Carboxylic Acids;Cinnamic acid;Organic acids;FINE Chemical & INTERMEDIATES;Aromatic Cinnamic Acids, Esters and Derivatives
Mol File:10538-51-9.mol
2,5-Dimethoxycinnamic acid Structure
2,5-Dimethoxycinnamic acid Chemical Properties
Melting point 147-150°C
Boiling point 267.4°C (rough estimate)
density 1.0627 (rough estimate)
refractive index 1.4389 (estimate)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
form powder to crystal
pka4.40±0.10(Predicted)
color Light orange to Yellow to Green
CAS DataBase Reference10538-51-9(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-37/39-37
WGK Germany 3
HazardClass IRRITANT
HS Code 29189900
MSDS Information
ProviderLanguage
2,5-Dimethoxycinnamic acid English
ACROS English
ALFA English
2,5-Dimethoxycinnamic acid Usage And Synthesis
Chemical Propertiesyellow powder
Uses2,5-Dimethoxycinnamic acid can be used as a pharmaceutical intermediate, and can be used in the synthesis of vasodilators such as cinnepazide.
PreparationSynthesis of 2,5-dimethoxycinnamic acid: 2,5-dimethoxybenzaldehyde, malonic acid and pyridine were added to 100ml three necks, piperidine was added at 90°C, refluxed for 2h, cooled to room temperature, and added 3mol/L hydrochloric acid, resulting in a large amount of white precipitate, suction filtration, the filter cake is washed with water, reconstituted with ethanol, after drying, 2,5-dimethoxycinnamic acid was obtained as pale yellow needle crystals.
DefinitionChEBI: 2,5-Dimethoxycinnamic acid is a hydroxycinnamic acid.
General Description2,5-Dimethoxycinnamic acid forms 1:1 molecular complex with 3,5-dinitrocinnamic acid.
trans-2,4,5-Trimethoxycinnamic acid alpha-Methylcinnamic acid AURORA 6677 3-PYRIDINYLMETHYL 6-METHOXY-2H-CHROMENE-3-CARBOXYLATE 3,4-Dimethoxycinnamonitrile 2,5-Dimethoxycinnamic acid Ascoric Acid 6-METHOXY-2H-CHROMENE-3-CARBOXYLIC ACID AURORA 6682 Ethyl 4-methoxycinnamate 6-METHOXY-2H-CHROMENE-3-CARBOXYLIC ACID ETHYL ESTER RARECHEM AL BK 0983 4-METHOXYBENZYL 6-METHOXY-2H-CHROMENE-3-CARBOXYLATE RARECHEM AL BM 0026 AURORA 6678 AURORA 6680 SALOR-INT L155268-1EA 2-BENZYLOXY-4,5-DIMETHOXYCINNAMIC ACID

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