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| | Gabapentin-lactam Basic information |
| | Gabapentin-lactam Chemical Properties |
| Melting point | 84-89 °C(lit.) | | Boiling point | 181 °C / 13mmHg | | density | 1.05±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | Soluble in DMSO (up to 40 mg/ml) | | pka | 16.39±0.20(Predicted) | | form | neat | | color | White | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. | | InChIKey | JAWPQJDOQPSNIQ-UHFFFAOYSA-N | | CAS DataBase Reference | 64744-50-9(CAS DataBase Reference) |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | RTECS | CM0120000 | | HazardClass | IRRITANT | | HS Code | 29337900 |
| | Gabapentin-lactam Usage And Synthesis |
| Description | Gabapentin lactam (CAS 64744-50-9) reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington’s disease.1 Displays neurotrophic effects, enhancing the formation of dendritic filopodia and inducing a network of F-actin-containing neurites in cultured hippocampal neurons.2 Promotes the survival of cultured central nervous system neurons possibly by opening mitochondrial KATP channels.3 Displays neuroprotective effects in a rat model of acute retinal ischemia.4 | | Chemical Properties | Gabapentin-lactam is White Solid
| | Uses | These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements. | | Uses | Gabapentin Lactam reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington disease. It opens mitochondrial ATP-dependent potassium channels | | Uses | Gabapentin-lactam reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington’s disease. It opens mitochondrial ATP-dependent potassium channels.
| | Definition | ChEBI: 2-Azaspiro[4.5]decan-3-one is an azaspiro compound. | | General Description | Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. | | References | 1) Zucker et al. (2004), Gabapentin-lactam, but not gabapentin, reduces protein aggregates and improves motor performance in transgenic mouse model of huntington’s disease; Nauyn Schmiedebergs Arch. Pharmacol., 370 131
2) Henle et al. (2006), Gabapentin-lactam induces dendritic filopodia and motility in cultured hippocampal neurons; J. Pharmacol. Exp. Ther., 319 181
3) Pielen et al. (2004), Retinal ganglion cell survival is enhanced by gabapentin-lactam in vitro: evidence for involvement of mitochondrial KATP channels; Graefes Arch. Clin. Exp. Ophthalmol., 242 240
4) Lagreze et al. (2001), The neuroprotective properties of gabapentin-lactam; Graefes Arch. Clin. Exp. Ophthalmol., 239 845 |
| | Gabapentin-lactam Preparation Products And Raw materials |
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