Febuprol

Febuprol Basic information
Product Name:Febuprol
Synonyms:(3-n-butoxy-2-hydroxypropyl)phenylether;1-butoxy-3-phenoxy-2-propano;1-butoxy-3-phenoxy-2-propanol;3-n-butoxy-1-phenoxy-2-propanol;h-33;k-10033;1-butoxy-3-(phenoxy)propan-2-ol;FEBUPROL
CAS:3102-00-9
MF:C13H20O3
MW:224.3
EINECS:221-454-8
Product Categories:API
Mol File:3102-00-9.mol
Febuprol Structure
Febuprol Chemical Properties
Melting point 25°C
Boiling point bp11 165°; bp1.0 125-132°
density d420 1.027
refractive index nD20 1.5004
storage temp. 2-8°C
CAS DataBase Reference3102-00-9(CAS DataBase Reference)
Safety Information
ToxicityLD50 in mice, rats (mg/kg): 3050, 2370 orally; 436, 400 i.p. (Hofrichter)
MSDS Information
Febuprol Usage And Synthesis
OriginatorValbil,Rohm Pharma,W. Germany,1981
DefinitionChEBI: Febuprol is an aromatic ether.
Manufacturing ProcessInitially, 4.5 g (0.08 mol) pulverized potassium hydroxide was dissolved in 300 ml isopropanol in a 500 ml four-neck flask equipped with stirrer, intensive cooler, dropping funnel and feed pipe for the gas treatment with nitrogen.
Then, 52.0 g (0.4 mol) n-butylglycidyl ether and 41.4 g (0.44 mol) phenol was added thereto, whereafter the material was heated to boiling under nitrogen. The material was stirred, about 8.5 hours, until no glycidyl ether could be determined, e.g., by gas chromatography.
After the suspension was cooled under nitrogen, the solvent was distilled off under vacuum. The residue was taken up in 200 ml water and the milky emulsion extracted exhaustively with ether. From the organic phase, the excess butylglycidyl ether was extracted with diluted potassium hydroxide solution. The ether phase was washed neutral with water and the solvent removed after drying with sodium sulfate. The remaining oily residue was distilled under vacuum; there was obtained a colorless liquid of BP 123.5°C/0.07 mm. Yield: 81.8 g (91.1% of the theory)

Therapeutic FunctionCholeretic
Febuprol Preparation Products And Raw materials
Raw materialsPhenol-->Potassium hydroxide-->Butyl glycidyl ether
Propane Phenylpropanolamine Amino-2-propanol 5-(TERT-BUTYL)-2-IODO-1,3-DIMETHYLBENZENE Anisole m-Anisyl alcohol (Trifluoromethoxy)benzene ALUMINUM TERT-BUTOXIDE Tetrabutyl titanate 1,4-Dioxane p-Anisic acid p-Anisaldehyde Allyl alcohol Isopropyl alcohol 3-Phenyl-1-propanol 3-Methoxybenzaldehyde 2-Phenoxyethanol 1-Propanol

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