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Nipecotic acid

Nipecotic acid Basic information
Product Name:Nipecotic acid
Synonyms:L-NIPECOTIC ACID;(3R)-(-)-PIPERIDIN-3-YLCARBOXYLIC ACID;(+/-)-3-PIPERIDINE CARBOXYLIC ACID;3-PIPERIDINECARBOXYLIC ACID;DL-NIPECOTIC ACID;DL-3-PIPERIDINECARBOXYLIC ACID;(-)-D-NIPECOTIC ACID;D(-)-NIPECOTIC ACID
CAS:498-95-3
MF:C6H11NO2
MW:129.16
EINECS:207-873-9
Product Categories:Miscellaneous Reagents;Heterocyclic Compounds;Piperidines, Piperidones, Piperazines;Piperidine;Miscellaneous;Unusual Amino Acids;Nitrogen cyclic compounds;Amines and Anilines;Amino Acids and Derivatives;Organic acids;Amino Acid Derivatives;GABA/Glycine receptor;Heterocycles
Mol File:498-95-3.mol
Nipecotic acid Structure
Nipecotic acid Chemical Properties
Melting point 261 °C (dec.) (lit.)
Boiling point 239.22°C (rough estimate)
density 1.1426 (rough estimate)
refractive index 1.4587 (estimate)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility water: soluble50mg/mL, clear, colorless to faintly yellow
form Solid
pkapK1:3.35(+1);pK2:10.64(0) (25°C)
color White
Water Solubility Soluble in water
Merck 14,6560
BRN 81096
CAS DataBase Reference498-95-3(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36-37/39
WGK Germany 3
RTECS TM6125380
HazardClass IRRITANT
HS Code 29339900
MSDS Information
ProviderLanguage
SigmaAldrich English
ACROS English
ALFA English
Nipecotic acid Usage And Synthesis
Chemical Propertiesoff-white to pale yellow-beige powder
Uses(+/-)-Nipecotic Acid (cas# 498-95-3) is a compound useful in organic synthesis.
DefinitionChEBI: A piperidinemonocarboxylic acid that is piperidine in which one of the hydrogens at position 3 is substituted by a carboxylic acid group.
Synthesis Reference(s)The Journal of Organic Chemistry, 28, p. 602, 1963 DOI: 10.1021/jo01037a531
General DescriptionR(?)-Nipecotic acid is a potential inhibitor of uptake of γ-aminobutyric acid (GABA) in rat brain slices. Lipophilic derivatives of nipecotic acid are used as drugs for the treatment of epilepsy.
Nipecotic acid Preparation Products And Raw materials
Preparation ProductsETHYL NIPECOTATE-->tert-butyl 4-(piperidine-3-carbonyl)piperazine-1-carboxylate-->1-(3-CHLORO-BENZYL)-PIPERIDINE-3-CARBOXYLIC ACID HYDROCHLORIDE-->1-(THIOPHENE-2-SULFONYL)-PIPERIDINE-3-CARBOXYLIC ACID-->Piperidine, 3-(1H-pyrazol-3-yl)- (9CI)-->1-BENZENESULFONYL-PIPERIDINE-3-CARBOXYLIC ACID
Triacetonediamine Ethyl 1-benzyl-4-oxo-3-piperidinecarboxylate hydrochloride 2,5-DIBROMOPIPERIDINE Hyaluronic acid BENZOYLECGONINE-D3 Ethyl 2-(Chlorosulfonyl)acetate Nipecotic acid N-Methyl-3-carbomethoxy-4-piperidone hydrochloride Ascoric Acid Diphenoxylate ECGONIN HCL Folic acid COCAINE PROPYL ESTER HCL VOACANGINE Haloperidol NIPECOTIC ACID ETHYL ESTER DROPERIDOL Citric acid
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