ChemicalBook Product Catalog Pharmaceutical intermediates Heterocyclic compound Pyridine compound Pyridine derivatives 1,8-Naphthyridine

1,8-Naphthyridine

1,8-Naphthyridine Basic information
Product Name:1,8-Naphthyridine
Synonyms:1,8-DIAZANAPHTHALENE;1,8-NAPHTHYRIDINE;PYRIDO[2,3-B]PYRIDINE;1,8-Pyridopyridine;1,8-Naphthyridine(6CI,7CI,8CI,9CI);1,8-NAPHTHYRIDINE 98+%;1,8-Diazanapthalene;1,8-Diazanaphthalene Pyrido[2,3-b]pyridine
CAS:254-60-4
MF:C8H6N2
MW:130.15
EINECS:
Product Categories:PYRIDINE
Mol File:254-60-4.mol
1,8-Naphthyridine Structure
1,8-Naphthyridine Chemical Properties
Melting point 99.8-99.9°C
Boiling point 248.9±13.0 °C(Predicted)
density 1.183±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
pka3.39
form powder to crystal
pka3.55±0.10(Predicted)
color White to Light yellow to Light orange
InChIKeyFLBAYUMRQUHISI-UHFFFAOYSA-N
CAS DataBase Reference254-60-4(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
HazardClass IRRITANT
HS Code 2902900000
MSDS Information
1,8-Naphthyridine Usage And Synthesis
Description1,8-Naphthyridine is an organic compound with the formula C8H6N2. It is the most well-studied of the six isomeric naphthyridines, a subset of diazanaphthalenes with nitrogen in the separate rings. Enoxacin, nalidixic acid, and trovafloxacin are 1,8-naphthyridine derivatives with antibacterial properties related to the fluoroquinolones.
Uses1,8-naphthyridine (napy) and its simplest 2-methyl and 2,7-dimethyl derivatives may act as monodentate and bidentate ligands, resembling the behavior of the carboxylate ligands.
DefinitionChEBI: 1,8-naphthyridine is a naphthyridine in which the nitrogens are situated at positions 1 and 8.
Purification MethodsPurify 1,8-naphthyridine through an Al2O3 column and elute with toluene and pet ether, evaporate the eluate, crystallise the residue from pet ether (b 60-80o), and sublime it at 80o/13mm. The picrate [15936-16-0] has m 207-208o (from EtOH), and the methiodide has m 180-181o (from EtOH). [Hawes & Wibberley J Chem Soc (C) 1564 1967, UV: Armarego Physical Methods in Heterocyclic Chemistry (Ed Katritzky, Academic Press) Vol III 134 1971, Beilstein 23 II 178, 23 III/IV 1237.]
1,8-Naphthyridine Preparation Products And Raw materials
Preparation ProductsNalidixic acid
7-amino-4-methyl-1,8-naphthyridin-2-ol 1,8-Naphthyridine 7-HYDRAZINO-2,4-BIS(TRIFLUOROMETHYL)[1,8]NAPHTHYRIDINE 4-hydroxy-7-methyl-1,8-naphthyridine-3-carboxylic acid N-(4-PHENOXYPHENYL)-5,7-BIS(TRIFLUOROMETHYL)[1,8]NAPHTHYRIDIN-2-AMINE 7-MORPHOLINO-2,4-BIS(TRIFLUOROMETHYL)[1,8]NAPHTHYRIDINE 5,7-BIS(TRIFLUOROMETHYL)[1,8]NAPHTHYRIDIN-2-YL 4-CHLOROPHENYL ETHER N-(4-CHLOROPHENYL)-5,7-BIS(TRIFLUOROMETHYL)[1,8]NAPHTHYRIDIN-2-AMINE N-(4-METHOXYPHENYL)-5,7-BIS(TRIFLUOROMETHYL)[1,8]NAPHTHYRIDIN-2-AMINE 7-(3,5-DIMETHYL-1H-PYRAZOL-1-YL)-2,4-BIS(TRIFLUOROMETHYL)[1,8]NAPHTHYRIDINE N-PHENYL-5,7-BIS(TRIFLUOROMETHYL)[1,8]NAPHTHYRIDIN-2-AMINE 7-CHLORO-2,4-BIS(TRIFLUOROMETHYL)[1,8]NAPHTHYRIDINE N-(2,4-DICHLOROPHENYL)-5,7-BIS(TRIFLUOROMETHYL)[1,8]NAPHTHYRIDIN-2-AMINE 4-([5,7-BIS(TRIFLUOROMETHYL)[1,8]NAPHTHYRIDIN-2-YL]AMINO)BENZENECARBONITRILE 5,7-BIS(TRIFLUOROMETHYL)[1,8]NAPHTHYRIDIN-2-YL 4-CHLOROPHENYL SULFIDE 5,7-BIS(TRIFLUOROMETHYL)-N-[3-(TRIFLUOROMETHYL)PHENYL][1,8]NAPHTHYRIDIN-2-AMINE N3-(5,7-DIMETHYL[1,8]NAPHTHYRIDIN-2-YL)-2-CHLORONICOTINAMIDE 7-(4-PHENYLPIPERAZINO)-2,4-BIS(TRIFLUOROMETHYL)[1,8]NAPHTHYRIDINE
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