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| | 1-Methoxy-2-propanol Basic information |
| | 1-Methoxy-2-propanol Chemical Properties |
| Melting point | -97 °C | | Boiling point | 118-119 °C(lit.) | | density | 0.922 g/mL at 25 °C(lit.) | | vapor density | 3.12 (vs air) | | vapor pressure | 10.9 mm Hg ( 25 °C) | | refractive index | n20/D 1.403(lit.) | | Fp | 93 °F | | storage temp. | Store at +2°C to +25°C. | | solubility | water: miscible | | pka | 14.49±0.20(Predicted) | | form | Liquid | | color | Colorless | | Odor | sweet ether-like odor | | PH | 4-7 (200g/l, H2O, 20℃) | | explosive limit | 1.7-11.5%(V) | | Water Solubility | soluble | | Sensitive | Hygroscopic | | BRN | 1731270 | | Exposure limits | TLV-TWA 100 ppm (370 mg/m3) (ACGIH); STEL 150 ppm (555 mg/m3) (ACGIH). | | Stability: | Stable. Highly flammable. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides, water. Moisture-sensitive. | | InChIKey | ARXJGSRGQADJSQ-UHFFFAOYSA-N | | LogP | 0.37 at 20℃ | | CAS DataBase Reference | 107-98-2(CAS DataBase Reference) | | NIST Chemistry Reference | Propan-2-ol, 1-methoxy-(107-98-2) | | EPA Substance Registry System | Propylene glycol 1-methyl ether (107-98-2) |
| Hazard Codes | T | | Risk Statements | 10-67-61 | | Safety Statements | 24-26-24/25-45-53 | | RIDADR | UN 3092 3/PG 3 | | WGK Germany | 1 | | RTECS | UB7700000 | | Autoignition Temperature | 532 °F | | TSCA | Yes | | HazardClass | 3 | | PackingGroup | III | | HS Code | 29094919 | | Hazardous Substances Data | 107-98-2(Hazardous Substances Data) | | Toxicity | dog,LD50,intravenous,2gm/kg (2000mg/kg),LUNGS, THORAX, OR RESPIRATION: DYSPNEABEHAVIORAL: ATAXIABEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD,Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 569, 1972. |
| | 1-Methoxy-2-propanol Usage And Synthesis |
| Chemical Properties | colourless liquid | | Chemical Properties | Propylene glycol monomethyl ether is a colorless liquid with a sweet ether-like
odor and bitter taste. It is soluble in water, ether, acetone, and benzene. | | Uses | 1-Methoxy-2-propanol is primarily used in the manufacture of
lacquers and paints, as an anti-freeze in industrial engines, a tailing agent for inks
used on very high-speed presses, a coupling agent for resins and dyes in waterbased
inks, and a solvent for celluloses, acrylics, dyes, inks, and stains. It is also
used in cleaning products such as glass and rug cleaners, carbon and grease
removers, and paint and varnish removers; and in pesticide formulations as a
solvent for applications to crops and animals. | | Uses | 1-Methoxy-2-propanol is used as a solvent for cellulose, acrylics, dyes, inks, and cellophane. | | Uses | 1-Methoxy-2-propanol acts as a good biological indicator. | | Uses | 1-Methoxy-2-propanol is mainly used as solvent, dispersant and diluent, as well as fuel antifreeze, extractant, etc. Used as solvent of nitrocellulose, compounding agent of brake oil and detergent, etc. Widely used in coatings and cleaners. It can be used as the active solvent of water-based coatings; Active solvent and coupling agent of solvent based printing ink; Solvent for ballpoint pens and pens; Coupling agents and solvents for household and industrial cleaners, derusting agents and hard surface cleaners; Solvents for agricultural pesticides; Mixed with propylene glycol n-butyl ether for glass cleaner formula. | | Uses | A glycol ether and a good biological indicator of exposure. | | General Description | A colorless liquid. Flash point near 89°F. Less dense than water. Contact irritates skin, eyes and mucous membranes. Prolonged exposure to vapors may cause coughing, shortness of breath, dizziness and intoxication. Vapors heavier than air. Used as a solvent and as an antifreeze agent. | | Air & Water Reactions | Highly flammable. Soluble in water. Oxidizes readily in air to form unstable peroxides that may explode spontaneously [Bretherick 1979 p.151-154, 164]. | | Reactivity Profile | 1-Methoxy-2-propanol is a methoxy alcohol derivative. The ether being relatively unreactive. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert them to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides. | | Hazard | Flammable, moderate fire risk. TLV: 100
ppm; STEL 150 ppm.
| | Health Hazard | VAPOR: Irritating to eyes, nose, and throat. LIQUID: Irritating to skin and eyes. | | Health Hazard | 1-Methoxy-2-propanol is a mild toxicant. The toxicity is lower than that of the methyl, ethyl, and butyl ethers of ethylene glycol. The toxic symptoms from inhaling high concentrations are nausea, vomiting, and general anesthetic effects. In humans, toxic effects may be felt at exposure to a level of 3000–4000 ppm.The oral and dermal toxicities in test animals were low. The effects were mild depression of the central nervous system and a slight change in liver and kidney. The recovery was rapid. Irritant actions on the skin and eyes of rabbits were low
LC50 value (rats): 7000 ppm /6 h
LD50 value (rats): 5660 mg/kg.
| | Fire Hazard | FLAMMABLE. Flashback along vapor trail may occur. Vapor may explode if ignited in an enclosed area. | | Flammability and Explosibility | Flammable | | Safety Profile | Moderately toxic by
intravenous route. Mildly toxic by ingestion,
inhalation, and skin contact. Human
systemic effects by inhalation: general
anesthesia, nausea. A skin and eye irritant.
An experimental teratogen. Many glycol
ethers have dangerous human reproductive
effects. Very dangerous fire hazard when
exposed to heat or flame; can react with
oxidizing materials. To fight fire, use foam,
CO2, dry chemical. When heated to
decomposition it emits acrid smoke and
irritating fumes. Used as a solvent and in
solvent-sealing of cellophane. See also
GLYCOL ETHERS and ETHYLENE
GLYCOL MONOMETHYL ETHER. | | Synthesis | 1-Methoxy-2-propanol is used as a reagent in the synthesis of 2-amino-3-carboxy-4-phenylthiophenes, which acts as a protein kinase C inhibitors. It is also used as a reagent in the synthesis of metolachlor. | | Potential Exposure | Propylene glycol monomethyl ether is
used as a solvent for coatings; cellulose esters and acrylics;
acrylics dyes; inks, and stains. It may also be used as
a heat-transfer fluid. | | Shipping | UN3092 1-Methoxy-2-propanol, Hazard Class: 3;
Labels: 3-Flammable liquid. | | Toxicity evaluation | Contact irritates skin, eyes and mucous membranes. Prolonged exposure to vapors may cause coughing, shortness of breath, dizziness and intoxication. Vapors heavier than air. Used as a solvent and as an antifreeze agent. The oral LD50 of rats was 6.6g/kg. The skin irritation is not obvious, but the toxic dose can be absorbed through the skin. The main manifestations of animal poisoning were inhibition and incomplete anesthesia. Half of the rats died when they were exposed to steam concentration of 40.18g/m3 for 5 ~ 6 hours. the impact of 1-methoxypropanol-2 (MEP) for the stimulation of an inflammatory response in human respiratory mucosa, we exposed 22 primary cell cultures of nasal respiratory epithelia of healthy individuals to MEP concentrations at the level of the German MAK-value (100ppm) and to the 10-fold concentration (1000ppm). | | Incompatibilities | Vapor may form explosive mixture
with air. Incompatible with oxidizers (chlorates, nitrates,
peroxides, permanganates, perchlorates, chlorine, bromine,
fluorine, etc.); contact may cause fires or explosions. Keep
away from alkaline materials, strong bases, strong acids,
oxoacids, epoxides, acid chlorides, acid anhydrides, isocya-
nates, aluminum, and copper. Hygroscopic (i.e., absorbs
moisture from the air). May slowly form reactive peroxides
during prolonged storage or on exposure to air and light. | | Waste Disposal | Dissolve or mix the
material with a combustible solvent and burn in a chemical
incinerator equipped with an afterburner and scrubber.
All federal, state, and local environmental regulations must
be observed. |
| | 1-Methoxy-2-propanol Preparation Products And Raw materials |
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