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| Product Name: | LITHIUM METHOXIDE | | Synonyms: | LITHIUM METHOXIDE;Methanol, lithiuM salt (1:1);LithiuM Methoxide solution ~10% in Methanol (T, ~2.2 M);LithiuM Methoxide, 2.20 M solution in Methanol, SpcSeal;Lithium methoxide solution 1.0 M in methanol;LITHIUM METHOXIDE, 1.0M SOLUTION IN METH YL ALCOHOL;LITHIUM METHYLATE SOLUTION, ~4.6 % IN ME THANOL;LITHIUM METHYLATE SOLUTION, ~10% IN METH ANOL | | CAS: | 865-34-9 | | MF: | CH3LiO | | MW: | 37.97 | | EINECS: | 212-737-7 | | Product Categories: | metal alkoxide;Organics | | Mol File: | 865-34-9.mol |  |
| | LITHIUM METHOXIDE Chemical Properties |
| Melting point | 500°C | | Boiling point | 64.6 °C | | density | 0.85 g/mL at 20 °C | | Fp | 52 °F | | storage temp. | Flammables area | | solubility | Soluble in methanol. | | form | powder | | Specific Gravity | 0.85 | | color | White | | Sensitive | Moisture Sensitive | | Hydrolytic Sensitivity | 7: reacts slowly with moisture/water | | BRN | 3552389 | | Stability: | Stable, but reacts violently with water. Highly flammable. Store under dry inert gas. | | CAS DataBase Reference | 865-34-9(CAS DataBase Reference) | | EPA Substance Registry System | Methanol, lithium salt (865-34-9) |
| | LITHIUM METHOXIDE Usage And Synthesis |
| Preparation | Lithium methoxide (3 cm3, 3mmol of 1.0M solution in methanol) was added to (11) (1.0 g, 2.8 mmol) in methanol (15 cm3) at 0 °C, with stirring, under an atmosphere of nitrogen. The mixture was stirred at room temperature for 67 h, then water (20 cm3) was added and the mixture extracted into dichloromethane (DCM). The DCM solution was dried (MgS04) and evaporated giving a solid ( 1.1 g) shown to consist of 4- methoxy-3,5-difluoro-2,6-dibromopyridine (22g) ( 19% ), 2,6-dibromo-4,5-dimethoxy-3- fluoropyridine (22h) (5%), (23b) (39% by comparison with authentic sample) and (23a) (36%). Neither column chromatography (eluting DCM and petrol 7: 3) nor preparative scale GLC ( 10% SE30, 140 oC) gave adequate separation of the products. However, a carbon nmr spectrum and GCMS of a mixture of (22g) and (23b) was obtained and the carbon spectra was assigned by comparison with that of (23b ). | | Chemical Properties | white powder | | Uses | Employed in sol-gel synthesis of lithium borophosphates. | | Uses | Lithium methoxide is used in sol-gel synthesis of lithium borophosphates. It is also useful for deprotonation reactions in organic synthesis. Further, it serves as a mild base in organic synthesis especially in transesterifications. | | Purification Methods | The most probable impurity is LiOH due to hydrolysis by moisture. It is important to keep the sample dry. It can be dried by keeping in a vacuum at 60-80o under dry N2 using an oil pump for a few hours. Store it under N2 in the cold. It should not have bands above 3000cm-1, IR has 1078, 2790, 2840 and 2930cm-1 in KBr. [Suebold J Org Chem 21 1561956, Beilstein 1 IV 1220, 1241.] |
| | LITHIUM METHOXIDE Preparation Products And Raw materials |
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