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| 6-Bromoquinoline Chemical Properties |
Melting point | 19°C | Boiling point | 116 °C / 6mmHg | density | 1.538 g/mL at 25 °C | refractive index | n20/D 1.663 | Fp | 19 °C | storage temp. | Inert atmosphere,2-8°C | solubility | Soluble in acetone, acetonitrile, dichloromethane, ethyl acetate and THF. | pka | 4.18±0.10(Predicted) | form | Oil | color | Thick | InChIKey | IFIHYLCUKYCKRH-UHFFFAOYSA-N | CAS DataBase Reference | 5332-25-2(CAS DataBase Reference) | NIST Chemistry Reference | 6-Bromo quinoline(5332-25-2) | EPA Substance Registry System | Quinoline, 6-bromo- (5332-25-2) |
| 6-Bromoquinoline Usage And Synthesis |
Bromoquinoline | There are seven positional isomers of bromoquinoline and their main properties are listed below:
| Application and synthetic method | 3-bromo-quinoline is reacted with mixed acid for generating 3-bromo-5-nitro-quinoline, which heats together with potassium permanganate for being oxidation into 5-bromo-2, 3-pyridine dicarboxylic acid.
6-bromo-quinoline is heated together with nitric acid to generate 6-bromo-8-nitro quinolone with further reaction with potassium permanganate for being oxidized to 2, 3-pyridinedicarboxylic acid.
2-bromo-quinolien can be synthesized through the reaction between 2-hydroxy quinoline and phosphorus pentabromide.
Quinoline perbromide is heated at 180 °C for generating 3-bromo-quinoline.
From the heating between 4-hydroxy quinoline and phosphorus pentabromide, or from the diazotization reaction via 4-aminoquinoline to generate 4-bromo-quinoline;
5-bromo-quinoline is synthesize by the heating reaction between m-bromo-aniline, glycerol, m-bromo nitrobenzene and concentrated sulfuric acid, or from the diazotization reaction of 5-aminoquinoline.
6-bromo-quinoline can be synthesized from the heating of bromoaniline, glycerol, concentrated sulfuric acid, and p-bromo-nitrobenzene.
7-bromo-quinoline can be synthesized from the diazotization reaction of 7-aminoquinoline.
8-bromo-quinoline can be synthesized from the heating reaction of o-bromo-aniline, glycerol, concentrated sulfuric acid and o-bromo nitrobenzene.
application: as organic synthesis reagents.
The above information is edited by the Chemicalbook of Dai Xiongfeng.
| Chemical Properties | Thick Oil | Uses | 6-Bromoquinoline is used as fine chemical and pharmaceutical intermediate, used as the coupling reagent. |
| 6-Bromoquinoline Preparation Products And Raw materials |
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