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Axitinib Impurity a

Axitinib Impurity a Basic information
Product Name:Axitinib Impurity a
Synonyms:Axitinib Impurity a;Axitinib Sulfoxide;N-Methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfinyl]benzamide;N-methyl-2-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfinyl]benzamide;Axitinib Impurity 5/Axitinib Sulfoxide/N-Methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfinyl]-benzamide;Benzamide, N-methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfinyl]-;Axitinib C;Axitinib sulfoxide (AG028458
CAS:1347304-18-0
MF:C22H18N4O2S
MW:402.47
EINECS:
Product Categories:
Mol File:1347304-18-0.mol
Axitinib Impurity a Structure
Axitinib Impurity a Chemical Properties
Melting point >225 (dec.)
Boiling point 720.6±60.0 °C(Predicted)
density 1.43±0.1 g/cm3(Predicted)
storage temp. Refrigerator
solubility DMSO (Slightly), Methanol (Slightly, Heated)
form Solid
pka11.70±0.40(Predicted)
color Light Yellow
Safety Information
MSDS Information
Axitinib Impurity a Usage And Synthesis
DescriptionAxitinib sulfoxide is a major inactive metabolite of the tyrosine kinase inhibitor axitinib . It is formed from axitinib primarily by the cytochrome P450 (CYP) isoform CYP3A4 with minor contributions from CYP3A5 and CYP2C19.
UsesAxitinib Sulfoxide is a major metabolite of Axitinib (A794650), a tyrosine kinase inhibitor. Axitinib is used in cancer therapy.
Axitinib Impurity a Preparation Products And Raw materials
Axitinib Impurity d Axitinib Impurity 3 Axitinib Impurity b BenzaMide, 2-[(3-iodo-1H-indazol-6-yl)thio]-N-Methyl- Axitinib Axitinib-13C-d3 3,6-DIIODO (1H)INDAZOLE 2-(1H-indazol-6-ylthio)-N-Methyl- BenzaMide Axitinib Impurity 13 Axitinib Impurity 18 Axitinib Impurity 20 Axitinib Impurity 4 Axitinib Impurity 10 Axitinib Impurity 26 Axitinib Impurity 23 Axitinib N-Glucuronide (M7) Axitinib Impurity 3 Axitinib Impurity 30
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