Di-o-tolylguanidine

Di-o-tolylguanidine Basic information
Product Name:Di-o-tolylguanidine
Synonyms:2,2'-DIMETHYLIMINOCARBANILIDE;1,3-DI-ORTHOTOLYL-GUANIDINE;1,3-DI-O-TOLYLGUANIDINE;1,3-DI-(2-TOLYL)GUANIDINE;1,3-Di-o-tolylguanidine;DI-O-TOLYLGUANIDINE;DTG;DOTG
CAS:97-39-2
MF:C15H17N3
MW:239.32
EINECS:202-577-6
Product Categories:Industrial/Fine Chemicals;Sigma receptor
Mol File:97-39-2.mol
Di-o-tolylguanidine Structure
Di-o-tolylguanidine Chemical Properties
Melting point 176-178 °C(lit.)
Boiling point 371.98°C (rough estimate)
density 1.1000
vapor pressure 0Pa at 25℃
refractive index 1.4560 (estimate)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility water: soluble70mg/mL at 20°C
form solid
pka10.32±0.10(Predicted)
color White
Water Solubility 70mg/L at 20℃
Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
LogP2.9 at 25℃
CAS DataBase Reference97-39-2(CAS DataBase Reference)
NIST Chemistry ReferenceGuanidine, 1,3-di-o-tolyl-(97-39-2)
EPA Substance Registry System1,3-Di-o-tolylguanidine (97-39-2)
Safety Information
Hazard Codes Xn
Risk Statements 22
Safety Statements 26-36
RIDADR UN 2811
WGK Germany 3
RTECS MF1400000
TSCA Yes
HazardClass 6.1(b)
PackingGroup III
HS Code 29252900
Hazardous Substances Data97-39-2(Hazardous Substances Data)
MSDS Information
ProviderLanguage
SigmaAldrich English
ALFA English
Di-o-tolylguanidine Usage And Synthesis
DescriptionDTG (97-39-2) is an agonist of the sigma (σ) receptor1?with roughly equal potency against both subtypes (σ1 and σ2 IC50’s ~ 30nM)2.
UsesDTG is a selective ligand for the sigma-binding site. DTG has high binding affinity.
DefinitionChEBI: 1,2-bis(2-methylphenyl)guanidine is a member of toluenes.
General Description1,3-Di-o-tolylguanidine is a selective σ-receptor agonist. 1,3-Di-o-tolylguanidine is σ site ligand and its interaction with dopamine drugs were studied in Wistar rats and Albino Swiss mice.
Flammability and ExplosibilityNonflammable
Biological ActivityDisplays high and roughly equal affinity for both σ 1 and σ 2 receptors.
Safety ProfilePoison by ingestion and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx.
Purification MethodsThe guanidine crystallises from aqueous EtOH. The sulfate has m 253-254o(dec, H2O). [Beilstein 12 H 803, 12 II 445, 12 III 1871, 16 IV 1764]
References1) Weber?et al.?(1986),?1,3-Di(2-[5-3H]tolyl)guanidine: a selective ligand that labels sigma-type receptors for psychotomimetic opiates and antipsychotic drugs; Proc. Natl. Acad. Sci. USA,?83?8784 2) Scherz?et al.?(1990),?Synthesis and Structure-Activity Relationships of N,N’-Di-o-tolylguanidine Analogues, High-Affinity Ligands for the Haloperidol-Sensitive σ Receptor; J. Med. Chem.,?33?2421
Di-o-tolylguanidine Preparation Products And Raw materials
Raw materialsguanidine-->Di-o-tolythiourea-->Cyanogen chloride-->2-Iodotoluene-->Carbon tetrachloride-->Guanidine nitrate-->Ammonia-->o-Toluidine
1,1-Di-o-tolylguanidine DI-O-TOLYLGUANIDINE SALT OF DICATECHOLBORATE RARECHEM AQ A4 0114 DI-ORTHO-TOLYLGUANIDINE SALT OF DICATECHOL BORATE 1-(4-AZIDO-2-METHYL [6-3H] PHENYL)-3-(2-METHYL [4,6-3H] PHENYL) GUANIDINE RARECHEM AQ A4 0066 DI-ORTHO-TOLYLGUANIDINE SALT OF DICATECHOL BORATE 2-Methyl-5-nitrobenzenesulfonic acid DI-ORTHO-TOLYLGUANIDINE SALT OF DICATECHOL BORATE,hydrogen bis[benzene-o-diolato(2-)-O,O']borate(1-), compound with N,N'-di-o-tolylguanidine (1:1) 1,3-DI-0-TOLYLGUANIDINE [5-3H]-,1,3-DI-O-TOLYLGUANIDINE DI-[P-RING-3H] 1-phenylguanidine Dicatechol borate, di-o-tolylguanidine salt DI-ORTHO-TOLYLGUANIDINE SALT OF DICATECHOL BORATE RARECHEM AQ A4 0091 DI-O-TOLYLGUANIDINE SALT OF DICATECHOLBORATE 3G [R] 2-Bromotoluene DI-ORTHO-TOLYLGUANIDINE SALT OF DICATECHOL BORATE 2-Methylbenzotrifluoride

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