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| | 2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl)-phenyl]-acetamide Basic information |
| Product Name: | 2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl)-phenyl]-acetamide | | Synonyms: | ICA-121431;2,2-DIPHENYL-N-(4-(N-THIAZOL-2-YLSULFAMOYL)PHENYL) ACETAMIDE;2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl)-phenyl]-acetamide;α-Phenyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-benzeneacetamide;alpha-Phenyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]benzeneacetamide;ICA-121431;ICA 121431;ICA121431;Benzeneacetamide, α-phenyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-;2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl | | CAS: | 313254-51-2 | | MF: | C23H19N3O3S2 | | MW: | 449.55 | | EINECS: | 809-095-0 | | Product Categories: | | | Mol File: | 313254-51-2.mol | ![2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl)-phenyl]-acetamide Structure](CAS/20150408/GIF/313254-51-2.gif) |
| | 2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl)-phenyl]-acetamide Chemical Properties |
| density | 1.409±0.06 g/cm3(Predicted) | | storage temp. | room temp | | solubility | DMSO: soluble20mg/mL, clear | | pka | 7.03±0.10(Predicted) | | form | powder | | color | white to beige | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. | | InChIKey | URSQNPPONHUJDL-UHFFFAOYSA-N |
| Hazard Codes | Xn | | Risk Statements | 22-36 | | Safety Statements | 26 | | WGK Germany | 3 |
| | 2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl)-phenyl]-acetamide Usage And Synthesis |
| Description | ICA 121431 is a voltage-gated sodium channel (Nav) blocker that selectively blocks Nav1.1 and Nav1.3 over Nav1.4, and Nav1.5-1.8 channels (IC50s = <20, 19, 240, and >10,000 nM, respectively). It induces a concentration-dependent hyperpolarizing shift in voltage dependence of inactivation of Nav1.3 channels at a concentration 1 μM but has no effect on resting channels. Substitution of the Nav1.3 domain IV voltage-sensor domain (VSD4) with the Nav1.5 VSD4 reduces ICA 121431 potency by approximately 500-fold. | | Uses | ICA 121431 is a voltage-gated sodium (Nav) channel inhibitor. | | storage | +4°C | | References | McCormack et al. (2013), Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels; Proc. Natl. Acad. Sci. USA 110 E2724
Ostenn et al. (2017), Pharmacology of the Nav1.1 domain IV voltage sensor reveals coupling between inactivation gating processes; Proc. Natl. Acad. Sci. USA 114 6836 |
| | 2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl)-phenyl]-acetamide Preparation Products And Raw materials |
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