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| Product Name: | PFI-1 | | Synonyms: | PFI-1;PFI-1 (PF-6405761);PFI-1 (PF-06405761);PFI 1;PFI1;CS-709;PF-06405761;Benzenesulfonamide, 2-methoxy-N-(1,2,3,4-tetrahydro-3-methyl-2-oxo-6-quinazolinyl)-;2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide PFI-1 (PF-6405761) | | CAS: | 1403764-72-6 | | MF: | C16H17N3O4S | | MW: | 347.39 | | EINECS: | | | Product Categories: | Inhibitors;Inhibitor | | Mol File: | 1403764-72-6.mol |  |
| | PFI-1 Chemical Properties |
| storage temp. | Sealed in dry,2-8°C | | solubility | DMSO: ≥10mg/mL | | form | powder | | color | white to beige |
| | PFI-1 Usage And Synthesis |
| Description | PFI 1 is a BET bromodomain inhibitor that exhibits inhibitory activity at BRD2 and BRD4. PFI-1 is a selective BET bromodomain inhibitor with activity at BRD2 (IC50 = 98 nM) and BRD4 (IC50 = 220 nM). PFI 1 induces apoptosis and G1 cell cycle arrest in BET inhibitor-sensitive cell lines (MV4;11). PFI 1 also downregulates Aurora B expression in MV4;11 cells. | | Uses | PFI-1 is used as a selective protein interaction inhibitor targetting BET bromodomains, used as regulators required for efficient expression of several growth promoting and anti-apoptotic genes. | | Definition | ChEBI: 2-methoxy-N-(3-methyl-2-oxo-1,4-dihydroquinazolin-6-yl)benzenesulfonamide is a member of quinazolines. | | storage | Store at RT |
| | PFI-1 Preparation Products And Raw materials |
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