ChemicalBook Product Catalog Biochemical Engineering Inhibitors protein tyrosine kinase OSI-420

OSI-420

OSI-420 Basic information
Product Name:OSI-420
Synonyms:Ethanol, 2-[[4-[(3-ethynylphenyl)aMino]-7-(2-Methoxyethoxy)-6-quinazolinyl]oxy]-, hydrochloride;OSI-420 (DesMethyl Erlotinib,CP-473420);CP-473420;DesMethyl Erlotinib;OSI-420 hydrochloride;OSI-420 (DesMethyl Erlotinib);Erlotinib O-DesMethyl Metabolite IsoMer (M14) HCl;6-O-Desmethyl Erlotinib 2
CAS:183320-51-6
MF:C21H22ClN3O4
MW:415.87
EINECS:200-258-5
Product Categories:Inhibitors
Mol File:183320-51-6.mol
OSI-420 Structure
OSI-420 Chemical Properties
storage temp. Store at -20°C
solubility DMSO : 50 mg/mL (120.23 mM; Need ultrasonic)
form Powder
Safety Information
MSDS Information
OSI-420 Usage And Synthesis
UsesOSI-420 (Desmethyl Erlotinib,CP-473420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor with IC50 of 2 and 20 nM for the inhibition of human EGFR and EGFR autophosphorylation in tumor cells.
UsesOSI 420 can be used in biological study of effects of cytochrome P 450 3A on pharmacokinetic interaction between erlotinib and docetaxel in rats.
targetEGFR
OSI-420 Preparation Products And Raw materials
Ethyl 3,4-dihydroxybenzoate Erlotinib iMpurity 2 4-Quinazolinamine,N-(3-ethenylphenyl)-6,7-bis(2-methoxyethoxy)-,hydrochloride(1:1) Erlotinib D6 HCl Erlotinib Impurity 1 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline Ponatinib OSI 413 DesMethyl Erlotinib Carboxylate Acid Erlotinib hydrochloride Erlotinib Imp.9 Neratinib Erlotinib Erlotinib IMpurity C Erlotinib Impurity 67 Imatinib mesylate 2-Amino-4,5-bis(2-methoxyethoxy)benzonitrile H-89 DIHYDROCHLORIDE HYDRATE
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