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N-De[2-(Methylsulfonyl)ethyl] Lapatinib

N-De[2-(Methylsulfonyl)ethyl] Lapatinib Basic information
Product Name:N-De[2-(Methylsulfonyl)ethyl] Lapatinib
Synonyms:N-De[2-(Methylsulfonyl)ethyl] Lapatinib;[6-(5-AMinoMethylfuran-2-yl)quinazolin-4-yl][3-chloro- 4-(3-fluorobenzyloxy)phenyl]aMine;6-[5-(AMinoMethyl)-2-furanyl]-N-[3-chloro-4-[(3-fluorophenyl)Methoxy]phenyl]-4-quinazolinaMine;Lapatinib Desmesylethyl Imp;Lapatinib impurity O;4-Quinazolinamine, 6-[5-(aminomethyl)-2-furanyl]-N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-;Lapatinib Desmesylethyl Impurity;6-(5-(aminomethyl)furan-2-yl)-N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)quinazolin-4-amine
CAS:697299-82-4
MF:C26H20ClFN4O2
MW:474.91
EINECS:
Product Categories:Aromatics;Heterocycles;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Sulfur & Selenium Compounds
Mol File:697299-82-4.mol
N-De[2-(Methylsulfonyl)ethyl] Lapatinib Structure
N-De[2-(Methylsulfonyl)ethyl] Lapatinib Chemical Properties
Melting point >141oC (dec.)
Boiling point 626.4±55.0 °C(Predicted)
density 1.376±0.06 g/cm3(Predicted)
storage temp. -20°C Freezer, Under inert atmosphere
solubility DMSO (Slightly), Methanol (Slightly, Heated)
pka8.83±0.29(Predicted)
form Solid
color Pale Yellow to Light Beige
Safety Information
MSDS Information
N-De[2-(Methylsulfonyl)ethyl] Lapatinib Usage And Synthesis
UsesA reactive metabolite of Lapatinib (L175800) which is associated with various drug toxicities. Lapatinib is metabolized mainly by P450 3A4 to form O- and N-dealkylated metabolites.
N-De[2-(Methylsulfonyl)ethyl] Lapatinib Preparation Products And Raw materials
Lapatinib iMpurity Lapatinib Impurity 16 Lapatinib Ditosylate O-De(3-fluorobenzyl) Lapatinib Lapatinib impurity L Lapatinib 4-Fluoro Impurity Lapatinib ditosylate Lapatinib IMpurity 8 Lapatinib IMpurity 10 LOXO-101 3-Chloro-4-(3-fluorobenzyloxy)aniline Lapatinib 2-Fluoro Impurity 5-[4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl]-2-furaldehyde Lapatinib IMpurity 2 Lapatinib impurity K Lapatinib Lapatinib
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