ChemicalBook Product Catalog Chemical Reagents Organic reagents Esters Methyl ester compound Methyl 3-aminocrotonate

Methyl 3-aminocrotonate

Methyl 3-aminocrotonate Basic information
Product Name:Methyl 3-aminocrotonate
Synonyms:METHYL-BETA-AMINOCROTONATE;METHYL 4-AMINOCROTONATE;METHYL 3-AMINOCROTONATE;METHYL 3-AMINO-2-BUTENOATE;AMINOCROTONIC ACID METHYL ESTER;3-AMINOCROTONATE METHYL ESTER;3-AMINOCROTONIC ACID METHYL ESTER;3-AMINO-2-BUTENOIC ACID METHYL ESTER
CAS:14205-39-1
MF:C5H9NO2
MW:115.13
EINECS:238-056-5
Product Categories:Aliphatics;Amines;API intermediates;14205-39-1
Mol File:14205-39-1.mol
Methyl 3-aminocrotonate Structure
Methyl 3-aminocrotonate Chemical Properties
Melting point 81-83 °C(lit.)
Boiling point 112°C 42mm
density 1.1808 (rough estimate)
vapor pressure 2.79-2.853hPa at 25℃
refractive index 1.4538 (estimate)
Fp 91 °C
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility 18g/l
pka5.27±0.70(Predicted)
form Crystalline Powder
color White to slightly yellow
PH8-9 (18g/l, H2O, 20℃)
Water Solubility insoluble
Sensitive Hygroscopic
BRN 956592
InChIKeyXKORCTIIRYKLLG-ONEGZZNKSA-N
LogP-0.27 at 25℃
CAS DataBase Reference14205-39-1(CAS DataBase Reference)
EPA Substance Registry System2-Butenoic acid, 3-amino-, methyl ester (14205-39-1)
Safety Information
Hazard Codes Xn
Risk Statements 22-36/37/38
Safety Statements 37/39-26-24/25
WGK Germany 3
RTECS EM9092500
TSCA Yes
HS Code 29224995
MSDS Information
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Methyl 3-aminocrotonate English
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Methyl 3-aminocrotonate Usage And Synthesis
Chemical PropertiesCrystals, yellowish-white
UsesMethyl 3-aminocrotonate (Methyl 3-amino-2-butenoate) was used to synthesize 4-aryl-1,4-dihydropyridines possessing potential calcium channel blocking activity.
UsesMethyl 3-aminocrotonate is used as intermediate for the syntheses of pharmaceuticals (e.g. 1,4-dihydropyridine derivatives) as well as for the manufacture of stabilizers and plastics. Product Data Sheet
UsesNitrendipine (N490150) metabolite. The pharmacokinetics of Nitrendipine was studied in the rat and 6 major metabolites were identified.
General DescriptionMethyl 3-aminocrotonate undergoes waste-free solid-state cascade reaction with crystalline ninhydrin.
Flammability and ExplosibilityNotclassified
Methyl 3-aminocrotonate Preparation Products And Raw materials
Preparation ProductsManidipine-->Amlodipine-->Nitrendipine-->Felodipine-->Benidipine-->Isradipine-->Nisoldipine-->Cilnidipine-->Phthaloyl amlodipine-->Lercanidipine hydrochloride-->2(1H)-PYRIDINONE, 4-HYDROXY-3,6-DIMETHYL--->Methyl 6-chloro-2-Methylnicotinate-->4-(2,3-Dichlorophenyl)-2,6-diMethyl-1,4-dihydropyridine-3,5-dicarboxylic acid-->Felodipine 3,5-DiMethyl Ester-->3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, methyl 3-(3-oxo-1,2-benzisothiazol-2(3H)-yl)propyl ester, S,S-dioxide
Nifedipine-d4 (2-nitrophenyl-d4) METHYL 2-(O-NITROBENZYLIDENE)-ACETOACETATE Nifedipine EP IMpurity-B METHYL 3-AMINOCROTONATE, (3-AMINOCROTONIC ACID METHYL ESTER),METHYL 3-AMINOCROTONATE, (3-AMINOCROTONIC ACID METHYL ESTER) Methyl Methyl 2-(methylamino)benzoate 4-Morpholineethanesulfonic acid Methyl carbamate ETHYL 3-(4-CHLOROANILINO)CROTONATE METHYL 4-(4-AMINOPHENYL)BUTANOATE Methyl-3-Aminocrotonate Diethyl2,6-dimethyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate METHYL-6-AMINOCROTONATE DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE 3-Amino-2-butenoic acid ethyl ester 2-HYDROXY-6-METHYL-4-PHENYL-1,4-DIHYDRO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER FATTY ACID METHYL ESTER MIX C8-C22 METHYL-Β-AMINOCROTONATE
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