5-Nitrothiophene-2-carboxylic acid

5-Nitrothiophene-2-carboxylic acid Basic information

Product Name:	5-Nitrothiophene-2-carboxylic acid
Synonyms:	RARECHEM AL BO 0544;5-Nitro-2-thenoic acid;5-NITRO-2-THIOPHENECARBOXYLIC ACID;5-NITROTHIOPHENE-2-CARBOXYLIC ACID;BUTTPARK 121\04-13;5-Nitro-2-ThiphenecarboxylicAcid;5-nitro-2-thiophenecarboxylic;2-Carboxy-5-nitrothiophene
CAS:	6317-37-9
MF:	C5H3NO4S
MW:	173.15
EINECS:	228-654-4
Product Categories:	Carboxylic Acids;Thiophenes & Benzothiophenes;Carboxylic Acids;Building Blocks;Heterocyclic Building Blocks;Thiophenes;Heterocycles;Thiophenes & Benzothiophenes;Thiophene&Benzothiophene
Mol File:	6317-37-9.mol

5-Nitrothiophene-2-carboxylic acid Chemical Properties

Melting point	154-159℃
Boiling point	367.2±27.0 °C(Predicted)
density	1.676±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
pka	2.69±0.10(Predicted)
form	Solid
color	Pale yellow
InChIKey	UNEPVPOHGXLUIR-UHFFFAOYSA-N
CAS DataBase Reference	6317-37-9(CAS DataBase Reference)

Safety Information

MSDS Information

Provider	Language
SigmaAldrich	English

5-Nitrothiophene-2-carboxylic acid Usage And Synthesis

Chemical Properties	Solid
Uses	5-Nitrothiophene-2-carboxylic Acid is a reagent used in the preparation of benzothiophene amides which fuctions as nicotinamide ribosyltransferase inhibitors with potential antitumor and anticancer activities. It also functions as an intermediate in varying organic transformations.
Synthesis Reference(s)	Canadian Journal of Chemistry, 44, p. 2881, 1966 DOI: 10.1139/v66-428 Journal of Medicinal Chemistry, 34, p. 2112, 1991

5-Nitrothiophene-2-carboxylic acid Preparation Products And Raw materials

Raw materials	Acetic acid-->Nitric acid-->Acetic anhydride-->2-Thiophenecarboxylic acid
Preparation Products	5-Amino-thiophene-2-carboxylic acid methyl ester

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