ALPHA-HYDROXY-GAMMA-BUTYROLACTONE

ALPHA-HYDROXY-GAMMA-BUTYROLACTONE Basic information
Product Name:ALPHA-HYDROXY-GAMMA-BUTYROLACTONE
Synonyms:DIHYDRO-3-HYDROXY-2(3H)-FURANONE;2-HYDROXY-GAMMA-BUTYROLACTONE;3-HYDROXYTETRAHYDROFURAN-2-ONE;AKOS 224;ALPHA-HYDROXY-GAMMA-BUTYROLACTONE;4,5-Dihydro-3-hydroxy-2(3H)-furanone;α-Hydroxy-γ-butyrolactone;4,5-Dihydroxy-3-hydroxy-2(3H)-furanone
CAS:19444-84-9
MF:C4H6O3
MW:102.09
EINECS:
Product Categories:
Mol File:19444-84-9.mol
ALPHA-HYDROXY-GAMMA-BUTYROLACTONE Structure
ALPHA-HYDROXY-GAMMA-BUTYROLACTONE Chemical Properties
Boiling point 133 °C/10 mmHg (lit.)
density 1.309 g/mL at 25 °C (lit.)
refractive index n20/D 1.468(lit.)
Fp >230 °F
storage temp. Inert atmosphere,Room Temperature
solubility Chloroform (Sparingly), Methanol (Slightly)
pka13.07±0.20(Predicted)
form Viscous Liquid
color Clear colorless to yellow
BRN 80587
InChIKeyFWIBCWKHNZBDLS-UHFFFAOYSA-N
LogP-1.830 (est)
CAS DataBase Reference19444-84-9(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 23-24/25-36-26
WGK Germany 3
3-10
HS Code 29322090
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
ALPHA-HYDROXY-GAMMA-BUTYROLACTONE Usage And Synthesis
Chemical Propertiesclear colorless to yellow viscous liquid
Usesα-Hydroxy-γ-butyrolactone may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis. 1 It may be employed as starting reagent in the synthesis of enantiomerically pure orthogonally protected δ-azaproline, via Mitsunobu reaction.
Usesα-Hydroxy-γ-butyrolactone may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis. It may be employed as starting reagent in the synthesis of enantiomerically pure orthogonally protected δ-azaproline, via Mitsunobu reaction.
General Descriptionα-Hydroxy-γ-butyrolactone is a 5-membered cyclic ester. It was obtained via tin-conversion of biomass-derived 1,3-dihydroxyacetone (DHA) and formaldehyde.
Purification MethodsIt has been purified by repeated fractionation and forms a colourless liquid. It has to be distilled at high vacuum; otherwise it will dehydrate. The acetox
ALPHA-HYDROXY-GAMMA-BUTYROLACTONE Preparation Products And Raw materials
Preparation Products2,4-dihydroxy-Butanoic acid-->2-Oxotetrahydrofuran-3-yl methacrylate
2-O-ACETYL-MALIC ANHYDRIDE (+)-DIACETYL-L-TARTARIC ANHYDRIDE L-GALACTONO-1,4-LACTONE 2,3-O-CYCLOHEXYLIDENE-L(-)-ERYTHRURONOLACTONE D-MANNONO-1,4-LACTONE L(+)-Gulonic acid gamma-lactone D-LYXONO-1,4-LACTONE (R)-(-)-BETA,BETA-DIMETHYL-ALPHA-HYDROXY-GAMMA-BUTYROLACTONE D-GLUCOHEPTONO-1,4-LACTONE D-Glucurono-6,3-lactone acetonide D-(-)-Gulonic acid gamma-lactone BETA,BETA-DIMETHYL-ALPHA-HYDROXY-GAMMA-BUTYROLACTONE (+)-DIBENZOYL-L-TARTARIC ANHYDRIDE D-GALACTONO-1,4-LACTONE (-)-4,5-O-CYCLOHEXYLIDENEQUINIC ACID LACTONE L-Mannono-1,4-lactone ALPHA,BETA-GLUCOOCTANOIC GAMMA-LACTONE D-SACCHARIC ACID 1,4-LACTONE

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