3-Fluoro-4-hydroxybenzaldehyde

3-Fluoro-4-hydroxybenzaldehyde Basic information

Product Name:	3-Fluoro-4-hydroxybenzaldehyde
Synonyms:	3-FLUORO-4-HYDROXYBENZALDEHYDE;4-HYDROXY-3-FLUOROBENZALDEHYDE;3-Fluoro-4-hydroxybenzaldehyde ,98%;2-Fluoro-4-formylphenol;Benzaldehyde, 3-fluoro-4-hydroxy-;uoro-4-hydroxybenzaL;3-Fluoro-4-hydroxybenzaldehyde>
CAS:	405-05-0
MF:	C7H5FO2
MW:	140.11
EINECS:	609-839-2
Product Categories:	Aromatic Aldehydes & Derivatives (substituted);Benzaldehyde;Fluorine series
Mol File:	405-05-0.mol

3-Fluoro-4-hydroxybenzaldehyde Chemical Properties

Melting point	121-124°C
Boiling point	225.6±20.0 °C(Predicted)
density	1.4710 (estimate)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
pka	6.52±0.18(Predicted)
form	powder to crystal
color	Light yellow to Yellow to Orange
Sensitive	Air Sensitive
BRN	3234259
InChIKey	QSBHJTCAPWOIIE-UHFFFAOYSA-N
CAS DataBase Reference	405-05-0(CAS DataBase Reference)

Safety Information

MSDS Information

Provider	Language
ALFA	English

3-Fluoro-4-hydroxybenzaldehyde Usage And Synthesis

Uses	3-Fluoro-4-hydroxybenzaldehyde can be used to synthesize 3-Cyclopropylmethoxy-4-difluoromethoxybenzoic Acid, which is an impurity and intermediate in the preparation of Roflumilast.
Chemical Properties	White crystalline powder
Uses	3-Fluoro-4-hydroxybenzaldehyde can be used to synthesize 3-Cyclopropylmethoxy-4-difluoromethoxybenzoic Acid (C988720), which is an impurity and intermediate in the preparation of Roflumilast (R639700).

3-Fluoro-4-hydroxybenzaldehyde Preparation Products And Raw materials

Raw materials	Sodium hydroxide-->Chloroform-->2-Fluorophenol
Preparation Products	4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDE-->3-broMo-5-fluoro-4-hydroxybenzaldehyde-->3-fluoro-4-(2-hydroxyethoxy)benzaldehyde-->3-Fluoro-4-hydroxy-5-nitrobenzaldehyde, 95%-->3-(3-fluoro-4-hydroxyphenyl)acrylic acid-->4-ETHOXY-3-FLUOROBENZALDEHYDE

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