2',6'-DIMETHYLACETANILIDE

2',6'-DIMETHYLACETANILIDE Basic information
Product Name:2',6'-DIMETHYLACETANILIDE
Synonyms:N-ACETYL-2,6-XYLIDINE;N-(2,6-DIMETHYL-PHENYL)-ACETAMIDE;TIMTEC-BB SBB008144;ALPHA,2',6'-DIMETHYLACETANILIDE;2',6'-DIMETHYLACETANILIDE;2,6-DIMETHYLACETANILIDE;2',6'-ACETOXYLIDIDE;2,6-Acetoxylide
CAS:2198-53-0
MF:C10H13NO
MW:163.22
EINECS:218-596-8
Product Categories:Anilines, Amides & Amines;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;1
Mol File:2198-53-0.mol
2',6'-DIMETHYLACETANILIDE Structure
2',6'-DIMETHYLACETANILIDE Chemical Properties
Melting point 182-184 °C(lit.)
Boiling point 290.31°C (rough estimate)
density 1.052
refractive index 1.5400 (estimate)
storage temp. 2-8°C
solubility Chloroform (Slightly), Methanol (Slightly)
pka15.14±0.70(Predicted)
form Solid
color Crystals
CAS DataBase Reference2198-53-0(CAS DataBase Reference)
EPA Substance Registry SystemAcetamide, N-(2,6-dimethylphenyl)- (2198-53-0)
Safety Information
Hazard Codes Xn
Risk Statements 20/21/22-36/37/38
Safety Statements 26-36
WGK Germany 3
RTECS AN7470000
TSCA Yes
HS Code 29242990
ToxicityLD50 orl-mus: 620 mg/kg TXAPA9 19,20,71
MSDS Information
ProviderLanguage
SigmaAldrich English
ACROS English
ALFA English
2',6'-DIMETHYLACETANILIDE Usage And Synthesis
Chemical Propertiesoff-white to yellow cryst. needles or cryst.powder
UsesLidocaine (L397800) impurity.
Synthesis Reference(s)Journal of the American Chemical Society, 106, p. 5759, 1984 DOI: 10.1021/ja00331a073
Chemical and Pharmaceutical Bulletin, 30, p. 4242, 1982 DOI: 10.1248/cpb.30.4242
Journal of Heterocyclic Chemistry, 2, p. 181, 1965 DOI: 10.1002/jhet.5570020214
General Description2,6-Dimethylacetanilide undergoes iodination by electrophylic substitution reaction of chloroacetanilide, in the presence of ferroiodide and copperchloride as catalyst, to form 4-iodine-2,6-dimethylacetanilide.
Safety ProfileModerately toxic by ingestion.When heated to decomposition it emits toxic fumes ofNOx.
2-Chloro-N-(2,6-dimethylphenyl)acetamide 4-[(2,6-DIMETHYLPHENYL)AMINO]-4-OXOBUTANOIC ACID 1-(2,6-DIMETHYL-PHENYL)-PYRROLE-2,5-DIONE 2',6'-DIMETHYLACETANILIDE N-(2,6-DIMETHYLPHENYL)MALEAMIC ACID N-(2,6-dimethylphenyl)-2-hydroxybenzamide N-(2,6-dimethylphenyl)-3-oxobutanamide LABOTEST-BB LT00012623 AURORA 10570 AURORA 2505 6-BROMO-4-METHYL-1-PHENYLANTHRAPYRIDONE 4-(MESITYLAMINO)-4-OXOBUT-2-ENOIC ACID AURORA 10571 AURORA 261 AURORA 6270 Lidocaine AURORA 10634 TIMTEC-BB SBB005915

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