5-Chloro-1-indanone

5-Chloro-1-indanone Basic information
Product Name:5-Chloro-1-indanone
Synonyms:5-chloro-2,3-dihydroinden-1-one;5-Chloro-1-indanone,98%;1-Indanone, 5-chloro-5- chlorineindon;5 - chlorine indene ketone;Chloro-1-indan;5-CHLORO-1-INDANONE;5-CHLOROINDAN-1-INDANONE;5-CHLOROINDAN-1-ONE
CAS:42348-86-7
MF:C9H7ClO
MW:166.6
EINECS:610-016-5
Product Categories:Building Blocks;C9;Carbonyl Compounds;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks;Benzocycles;Indane/Indanone and Derivatives;Ketones;Indanone & Indene;42348-86-7
Mol File:42348-86-7.mol
5-Chloro-1-indanone Structure
5-Chloro-1-indanone Chemical Properties
Melting point 94-98 °C (lit.)
Boiling point 124-125 °C (3 mmHg)
density 1.1466 (rough estimate)
refractive index 1.6000 (estimate)
Fp 124-125°C/3mm
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Chloroform (Slightly)
form Solid
color Light Beige to Beige
Water Solubility insoluble
BRN 1448000
InChIKeyMEDSHTHCZIOVPU-UHFFFAOYSA-N
CAS DataBase Reference42348-86-7(CAS DataBase Reference)
NIST Chemistry Reference5-Chloro-1-indanone(42348-86-7)
EPA Substance Registry System1H-Inden-1-one, 5-chloro-2,3-dihydro- (42348-86-7)
Safety Information
Hazard Codes Xn,Xi
Risk Statements 20/21/22-36/37/38
Safety Statements 26-36
WGK Germany 3
Hazard Note Irritant
TSCA Yes
HS Code 29339900
MSDS Information
ProviderLanguage
SigmaAldrich English
ACROS English
ALFA English
5-Chloro-1-indanone Usage And Synthesis
Chemical PropertiesWhite Crystal
Uses5-Chloro-1-indanone is the important intermediate of du pont company's new varieties of pesticides indoxacarb (popular name: indoxacarb), is also a kind of important medicine intermediate simultaneously.
5-Chloro-1-indanone is a 5-halo-1-indanone. It participates in the Irie′s synthesis of substituted pyridines. 5-Chloro-1-indanone has a stable triclinic crystal structure and has intermolecular forces of C-H...O, C-H...Π, CO...Cl and Π...Π types.
5-Chloro-1-indanone may be used as starting reagent for the preparation of 5-chloro-2-methoxycarbonyl-1-indanone. It may be used for the preparation of important biomedical compounds such as anticonvulsants, anticholinergics and diarylsulfonylureas, having potential activity against solid tumors.

Uses5-Chloro-1-indanone may be used as starting reagent for the preparation of 5-chloro-2-methoxycarbonyl-1-indanone. It may also be used for the preparation of important biomedical compounds such as anticonvulsants, anticholinergics and diarylsulfonylureas, having potential activity against solid tumors. It participates in the Irie?s synthesis of substituted pyridines.
Preparation3-chlorobenzaldehyde as raw material first reacts with propionic acid to prepare 3-chloro-phenylpropionic acid, which is then subjected to Friedel-Crafts acylation reaction to prepare 5-chloro-1-indanone. Organic solvents of formic acid diethylamine participate in the first step, and the reaction temperature is 20-150℃. An organic solvent of methylene chloride and a catalyst of zinc chloride participate in the second step, and the reaction temperature is -10 to 80 ℃.
Synthetic method of 5-chloro-1-indanone
General Description5-Chloro-1-indanone is a 5-halo-1-indanone. It participates in the Irie′s synthesis of substituted pyridines. 5-Chloro-1-indanone has a stable triclinic crystal structure and has intermolecular forces of C-H...O, C-H...Π, CO...Cl and Π...Π types.
5-Chloro-1-indanone Preparation Products And Raw materials
Preparation ProductsAprindine-->Spiro[imidazolidine-4,1'-[1H]indene]-2,5-dione, 5'-chloro-2',3'-dihydro--->4-Chlorophthalimide
1-Indanone 5-Chloro-2-hydroxy-2-methoxycarbonyl-1-indanone 5-Chloro-1-indanone Neosperidin dihydrochalcone Hydrochlorothiazide Difluorochloromethane 5,6-DICHLORO (DIFLUORO)-INDANONE 5-CHLORO-1-INDANONE, [1-14C] TCID cis-Octahydro-isoindole 5-CHLORO-6-METHOXY-1-INDANONE, 97% 6-CHLORO-5-CYCLOHEXYL-3-OXOINDAN-1-CARBOXYLIC ACID Chlormezanone 7-CHLORO-1-INDANONE TERT-BUTYL 6-CHLORO-3-OXO-2,3-DIHYDROSPIRO[INDENE-1,4'-PIPERIDINE]-1'-CARBOXYLATE 5,7-Dichloro-2,3-dihydroinden-1-one 5-CHLORO-2-TRIFLUOROACETYL-1-INDANONE Pigment Yellow 138

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