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BENAZEPRILAT

BENAZEPRILAT Basic information
Product Name:BENAZEPRILAT
Synonyms:BENAZEPRILAT;BENAZEPRILAT HCL HYDRATE;Benazepril hydrochloride impurity C;Benazepril Impurity 3(Benazepril EP Impurity C);(3S)-3-[[(S)-1-Carboxy-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid;CGS-14831;Benazepril Related Compound C (50 mg) ((3S)-3-[[(1S)-1- carboxy-3-phenylpropyl]amino-2,3,4,5-tetrahydro-2-oxo- 1H-1-benzazepine]-1-acetic acid);(3S)-3-[[(1S)-1-carboxy-3-phenylpropyl]aMino-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine]-1-acetic acid
CAS:86541-78-8
MF:C22H24N2O5
MW:396.44
EINECS:
Product Categories:Intermediates & Fine Chemicals;Metabolites;Pharmaceuticals;Aromatics;Heterocycles;Metabolites & Impurities;Chiral Reagents
Mol File:86541-78-8.mol
BENAZEPRILAT Structure
BENAZEPRILAT Chemical Properties
Melting point 270-272°C
alpha D -200.5° (c = 1 in 3% aqueous NH4OH)
Boiling point 711.3±60.0 °C(Predicted)
density 1.34±0.1 g/cm3(Predicted)
storage temp. -20°C Freezer, Under Inert Atmosphere
solubility Aqueous Base (Slightly), DMSO (Slightly)
form Solid
pka2.17±0.10(Predicted)
color White to Off-White
CAS DataBase Reference86541-78-8
Safety Information
HS Code 2933790002
MSDS Information
BENAZEPRILAT Usage And Synthesis
Chemical PropertiesCrystalline Solid
UsesBenazeprilat is a metabolite of Benazepril, which is used as an antihypertensive.
DefinitionChEBI: A benzazepine that is 1,3,4,5-tetrahydro-2H-1-benzazepin-2-one in which the hydrogen attached to the nitrogen is replaced by a carboxy methyl group and in which the 3-pro-S hydrogen is replaced by the amino roup of (2S)-2-amino-4-phenylbutanoic acid. An angiotensin-converting enzyme inhibitor, it is used as its monoester prodrug benazepril in the treatment of hypertension and heart failure.
BENAZEPRILAT Preparation Products And Raw materials
BENAZEPRIL-D5 HYDROCHLORIDE (S)-3-AMino-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic Acid BENAZEPRILAT-D5 Benazeprilat Acyl--D-glucuronide BENAZEPRILAT BENAZEPRIL ACYL-B-D-GLUCURONIDE BENAZEPRILAT MM Benazepril hydrochloride Benazeprilat-d5 Acyl--D-glucuronide BENAZEPRILAT ACYL-B-D-GLUCURONIDE S-ATBA BENAZEPRIL-D5 ACYL-B-D-GLUCURONIDE BENAZEPRIL RELATED COMPOUND A (15 MG) ((3R)-3-[[(1 R)-1 -(ETHOXYCARBONYL)-3-PHENYLPROPYL]AMI-NO]-2,3,4,5-TETRAHYDRO-2-OXO-1 H-1 -BENZAZEPINE-1-ACETIC ACID, MONOHYDROCHLORIDE) BENAZEPRILAT-D5 ACYL-B-D-GLUCURONIDE BENAZEPRIL TERT-BUTYL ESTER D5 BENAZEPRIL RELATED COMPOUND B (15 MG) ((3S)-3-[[(1 R)-1 -(ETHOXYCARBONYL)-3-PHENYLPROPYL]AMI-NO]-2,3,4,5-TETRAHYDRO-2-OXO-1 H-1 -BENZAZEPINE-1-ACETIC ACID, MONOHYDROCHLORIDE) BENAZEPRIL-D5 BENAZEPRILAT MM(CRM STANDARD)
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