4-Acetylpyridine

4-Acetylpyridine Basic information

Product Name:	4-Acetylpyridine
Synonyms:	METHYL 4-PYRIDYL KETONE;4-ACETYLPYRIDINE;AKOS BBS-00003233;gamma-Acetylpyridine;1-(4-pyridinyl)-ethanon;1-(4-Pyridinyl)ethanone;1-pyridin-4-yl-ethanone;4-acetyl-pyridin
CAS:	1122-54-9
MF:	C7H7NO
MW:	121.14
EINECS:	214-350-9
Product Categories:	Heterocycle-Pyridine series;Heterocyclic Compounds;ACETYLGROUP;Pyridine;CHIRAL CHEMICALS;bc0001
Mol File:	1122-54-9.mol

4-Acetylpyridine Chemical Properties

Melting point	13-16 °C(lit.)
Boiling point	212 °C(lit.)
density	1.095 g/mL at 25 °C(lit.)
refractive index	n20/D 1.529(lit.)
Fp	>230 °F
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform, Ethyl Acetate
pka	pK1: 3.505(+1) (25°C)
form	Liquid
color	brown-yellowish
Specific Gravity	1.110 (20/4℃)
Water Solubility	insoluble
BRN	107629
InChIKey	WMQUKDQWMMOHSA-UHFFFAOYSA-N
LogP	0.480
CAS DataBase Reference	1122-54-9(CAS DataBase Reference)
NIST Chemistry Reference	Ethanone, 1-(4-pyridinyl)-(1122-54-9)
EPA Substance Registry System	4-Acetylpyridine (1122-54-9)

Safety Information

Hazard Codes	Xi,Xn
Risk Statements	36/37/38-36/38-22
Safety Statements	26-36-37/39
WGK Germany	3
RTECS	OB5426000
F	8
Hazard Note	Irritant
TSCA	Yes
HS Code	29333999

MSDS Information

Provider	Language
Methyl 4-pyridyl ketone	English
SigmaAldrich	English
ACROS	English
ALFA	English

4-Acetylpyridine Usage And Synthesis

Chemical Properties	clear light yellow to brownish liquid
Uses	4-Acetylpyridine is a acetylated pyridine used in the preparation of nitrogen containing bicyclic heterocycles and other organic compounds. 4-Acetylpyridine is also present in mainstream cigarette smo ke.
Uses	4-acetylpyridine on reaction with - and 4-formylpyridine (H3FoPyS, H4FoPyS) yields semicarbazones. Reaction of acetylpyridine with thiophene-2-carboxaldehyde afforded the 2-chloro-6-ethoxy-4-β-(2-thienyl)acryloylpyridine, which was reacted with malononitrile in refluxing ethanol in the presence of piperidine as a catalyst to afford the cyanoaminopyrane derivative.
General Description	Dark amber liquid.
Air & Water Reactions	Soluble in water.
Reactivity Profile	4-Acetylpyridine is incompatible with strong oxidizing agents and strong reducing agents. . Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
Fire Hazard	4-Acetylpyridine is probably combustible.

4-Acetylpyridine Preparation Products And Raw materials

Preparation Products

1-(3-AMINO-2-CHLORO-PYRIDIN-4-YL)-ETHANONE-->4-Pyridineethanol-->1-(3-AMINO-PYRIDIN-4-YL)-ETHANONE-->PYRIDINE-4-ACETIC ACID-->5-PYRIDIN-4-YL-4H-PYRAZOLE-3-CARBOXYLIC ACID-->ETHYL 2-OXO-2-(PYRIDIN-4-YL)ACETATE-->3PO-->4-(Bromoacetyl)pyridine hydrobromide-->1-PYRIDIN-4-YL-ETHYLAMINE-->4',4''''-(1,4-PHENYLENE)BIS(2,2':6',2''-TERPYRIDINE)-->ETHYL ISONICOTINOYLACETATE-->2-methyl-4-(pyridin-4-yl)pyrimidine-->4-(4-PYRIDINETHIOACETYL)MORPHOLINE-->2-Pyridinecarboxamide, 4-acetyl- (9CI)-->ethyl 2-amino-4-(4-pyridinyl)-3-thiophenecarboxylate-->6’-(pyridin-4-yl)-3,4’:2’,4’’-terpyridine-->2-(4-Methylphenyl)-1-(4-pyridinyl)-ethanone-->1-(4-PYRIDINYL)-1,3-BUTANEDIONE

Sulfasalazine Acetylspiramycin Acetylcholine N-ACETYL-L-TYROSINE ETHYL ESTER Acetaminophen 4-Acetylpyridine tributyl acetocitrate Acetylsalicylic acid 2,6-Diacetylpyridine Tribenuron methyl Kresoxim-methyl Chromium picolinate 2-Acetylpyridine ,98%,2-ACETYLPYRIDINE Thiophanate-methyl Methyl salicylate Pyridine Methyl acetate 3-ACETYLPYRIDINE,beta-Acetylpyridine,3-ACETYLPYRIDINE 99+%

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