D-(-)-MANDELIC ACID BENZYL ESTER Usage And Synthesis
Description
(R)-benzyl Mandelate is a synthetic intermediate useful for pharmaceutical synthesis.
Uses
Benzyl (R)-(-)-mandelate can be employed as reactant to synthesize:
(S)-α-Hydroxy-N-(2-phenylethyl)benzenepropanamide (α-hydroxyamides) by enzyme catalyzed amidation reaction.
Optically pure (R)- monomethyl esters of 3-[(tert-butyldimethylsilyl)oxy]pentanedioic acid, which is employed in the preparation of HMG-CoA reductase inhibitors.
O-Ibuprofenylmandelic acid via acylation reaction with optically active ibuprofen and subsequent hydrogenation.
Benzyl (R)-2-fluoro-2-phenylacetate via deoxyfluorination of alcohols using AlkylFluor.
It can also be used to prepare HMG-CoA reductase inhibitors.
Uses
D-(-)-Mandelic Acid Benzyl Ester is a useful reagent for the preparation of a pharmaceutical composition for treating atopic dermatitis.
D-(-)-MANDELIC ACID BENZYL ESTER Preparation Products And Raw materials
