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| | Polygalacic acid Basic information |
| Product Name: | Polygalacic acid | | Synonyms: | Polygalacic acid;Polygalacic;(2b,3b,4a,16a)-2,3,16,23-Tetrahydroxyolean-12-en-28-oic acid;Olean-12-en-28-oicacid, 2,3,16,23-tetrahydroxy-, (2β,3β,4,16)-;Virgaureagenin G;(4R)-2β,3β,16α,23-Tetrahydroxyolean-12-en-28-oic acid;Polygalacic acid or (2b,3b,4a,16a)-2,3,16,23-Tetrahydroxyolean-12-en-28-oic acid;Polygalacic acid
(2b,3b,4a,16a)-2,3,16,23-Tetrahydroxyolean-12-en-28-oic acid | | CAS: | 22338-71-2 | | MF: | C30H48O6 | | MW: | 504.7 | | EINECS: | | | Product Categories: | chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract | | Mol File: | 22338-71-2.mol |  |
| | Polygalacic acid Chemical Properties |
| Melting point | 300-305 °C (sublm) | | Boiling point | 638.1±55.0 °C(Predicted) | | density | 1.23±0.1 g/cm3(Predicted) | | storage temp. | 4°C, protect from light | | solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | | form | Powder | | pka | 4.41±0.70(Predicted) |
| | Polygalacic acid Usage And Synthesis |
| Uses | Polygalacic acid can be used to calm the nerves, eliminate phlegm, reduce swelling, etc. It is mostly used clinically to treat bronchitis, induce labor, and induce labor. | | Biological Activity | Polygalacic acid is a triterpenoid tetrahydroxy acid isolated from Polygala paenea L.. It (0-100μM; 24h) can significantly reduce the mRNA expression of MMP-3, MMP-9, MMP-13 and COX-2, and the expression of these factors can be significantly increased by IL-1β in a dose-dependent manner . | | in vitro | Polygalacic acid (0-100 μM; 24 hours) significantly decreases the mRNAexpressions of MMP-3, MMP-9, MMP-13, and COX-2, which are significantly increased by IL-1β, in a In a dose-dependent manner. Polygalacic acid (0-100 μM; 6 hours) decreases the expression of phosphor-p38, phosphor-Erk, and phosphor-Jnk induced by IL-1β, phosphor-p65 is not reduced by polygalacic acid. RT-PCR | Cell Line: | Chondrocyte cells | | Concentration: | 50 μM; 100 μM | | Incubation Time: | 24 hours | | Result: | Suppressed IL-1β-induced COX-2, MMP3, MMP9, and MMP13 mRNA expression. | Western Blot Analysis | Cell Line: | Chondrocyte cells | < tr> Concentration: | 50 μM; 100 μM | | | Incubation Time : | 6 hours | | Result: | Inhibited the IL-1β-induced activation of the MAPK pathway in chondrocytes. |
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