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| | Obatoclax mesilate Basic information |
| Product Name: | Obatoclax mesilate | | Synonyms: | OBATOCLAX MESYLATE;2-[2-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-3-methoxy-2H-pyrrol-5-yl]-1H-indole methanesulfonate;Obatoclax mesilate;1H-Indole, 2-(2-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-3-methoxy-2H-pyrrol-5-yl)-, monomethanesulfonate;Gx 15-070;Gx 15-070ms;Gx015-070;Unii-39200fj43j | | CAS: | 803712-79-0 | | MF: | C20H19N3O.CH4O3S | | MW: | 413.49 | | EINECS: | 804-325-6 | | Product Categories: | Inhibitors;Inhibitor;INDOLE | | Mol File: | 803712-79-0.mol |  |
| | Obatoclax mesilate Chemical Properties |
| storage temp. | -20°C | | solubility | Soluble in DMSO (up to 5 mg/ml). | | form | solid | | color | Purple | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| | Obatoclax mesilate Usage And Synthesis |
| Description | Obatoclax (803712-79-0) is a novel Bcl-2 homology domain-3 (BH3) mimetic.1?Inhibits primary acute myeloid leukemia (AML) progenitor cell proliferation (IC50=0.18 μM) and induces apoptosis in primary AML cells (IC50= 3.6 μM).2?Obatoclax synergizes with other agents such as chloroquine3?and cytarabine4?in cytotoxicity against a variety of cancer cells. | | Chemical Properties | Red powder | | Uses | Obatoclax (GX15-070) is an inhibitor of Bcl-2 with Ki of 0.22 μM. | | Uses | Obatoclax Mesylate is a novel Bcl-2 homology domain-3 (BH3) mimetic. | | storage | Store at -20°C | | References | 1) Chonghaile and Letai (2008),?Mimicking the BH3 domain to kill cancer cells; Oncogene,?27?S149
2) Konopleva?et al. (2008),?Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070 (obatoclax); Cancer Res.,?68?3413
3) Wang?et al. (2014),?Combination of chloroquine and GX15-070 (obatoclax) results in synergistic cytotoxicity against pancreatic cancer cells; Oncol. Rep.,?32?2789
4) Xie?et al. (2015),?Obatoclax potentiates the cytotoxic effect of cytarabine on acute myeloid leukemia cells by enhancing DNA damage; Mol. Oncol.,?9?409 |
| | Obatoclax mesilate Preparation Products And Raw materials |
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