ChemicalBook Product Catalog Chemical Reagents Organic reagents Thiourea noxytiolin

noxytiolin

noxytiolin Basic information
Product Name:noxytiolin
Synonyms:noxytiolin;Noxythiolin;1-(Hydroxymethyl)-3-methylthiourea;Gynaflex;Noxyflex S;Noxytioline;(methylamino-λsup4sup-sulfanylidyne)methylamino]methanol;Noxythioline
CAS:15599-39-0
MF:C3H8N2OS
MW:120.17
EINECS:2396795
Product Categories:
Mol File:15599-39-0.mol
noxytiolin Structure
noxytiolin Chemical Properties
Melting point 88-90°
Boiling point 203.7±42.0 °C(Predicted)
density 1.223±0.06 g/cm3(Predicted)
pka13.45±0.10(Predicted)
Safety Information
ToxicityLD50 orally in mice: >3 g/kg (Aebi, Hafstetter)
MSDS Information
noxytiolin Usage And Synthesis
OriginatorNoxyflex,Geistlich,UK,1964
DefinitionChEBI: Noxytiolin is a member of thioureas.
Manufacturing Process400 g methyl thiourea and 2.5 g NaHCO3 are dissolved in 400 ml formaldehyde solution of 35% concentration. After having been left at ordinary temperature for 2 to 3 hours, the solution is adjusted with dilute HCl to pH 7 to 7.5. After the reaction mixture had been left overnight at 15°C some of the final product crystallized and was filtered off using a Buchner funnel. The mother liquor was concentrated by evaporation in vacuo at a bath-temperature of 30°C. The crystals obtained were again collected by filtration using a Buchner funnel and were combined with the first crystalline fraction and dried in vacuo at ordinary temperature. Yield of pure substance 400 g; melting point 84°C to 86°C.
Therapeutic FunctionAntifungal
noxytiolin Preparation Products And Raw materials
Raw materialsFormaldehyde-->N-METHYLTHIOUREA
8-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-N-(4-NITROPHENYL)-1-OXA-4,8-DIAZASPIRO[4.5]DECANE-4-CARBOTHIOAMIDE Carbimazole THIOPHANAT-ETHYL 5-METHYL-2-THIOURIDINE N-methoxycarbonyl N'-2-nitro-4-trifluoromethylphenyl thiourea DIMETHYLOLTHIOUREA N-[(1,2,3,4-TETRAHYDROPYRIDO[4,3-B][1,8]NAPHTHYRIDIN-2-YL)THIOCARBONYL]CARBAMIC ACID, ETHYL ESTER 4,5-DIHYDROXY-1-PHENYL-IMIDAZOLIDINE-2-THIONE BUTTPARK 11\07-03 1-(Hydroxymethyl)-4-phenyl-2-tetrazoline-5-thione 2-THIO-6-AZAURIDINE 6-METHOXY-2-THIOXO-2,3-DIHYDRO-1H-PYRIMIDIN-4-ONE Thiophanate-methyl 4,5-DIMETHOXY-IMIDAZOLIDINE-2-THIONE N-ALLYL-8-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-1-OXA-4,8-DIAZASPIRO[4.5]DECANE-4-CARBOTHIOAMIDE 7-AMINO-4-OXO-5-PHENYL-2-THIOXO-1,3,5,8-TETRAHYDRO-8-OXAQUINAZOLINE-6-CARBONITRILE Thibenzazoline 7,7,8A-TRIMETHYL-5-THIOXO-TETRAHYDRO-OXAZOLO[3,2-C]PYRIMIDIN-2-ONE
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