tipepidine

tipepidine Basic information

Product Name:	tipepidine
Synonyms:	14698-07-8 (Citrate[1:1]);1-Methyl-3-piperidylidenedi(2-thienyl)methane;3-(Di-2-thienylmethylene)-1-methyl-piperidine;At 327;Bitiodin;Brn 0212554;Cr/662;3-(Dithien-2-ylmethylene)-1-methylpiperidine
CAS:	5169-78-8
MF:	C15H17NS2
MW:	275.43
EINECS:
Product Categories:
Mol File:	5169-78-8.mol

tipepidine Chemical Properties

Safety Information

Toxicity

LD50 in mice (mg/kg): 294 i.p.; 308 i.m.; 867 orally (Higaki)

MSDS Information

tipepidine Usage And Synthesis

Originator	Sotal,G. Ramon
Definition	ChEBI: Tipepidine is a member of piperidines.
Manufacturing Process	From ethyl 1-methylpiperidine-3-carboxylate (which was prepared by hydrogenation of ethyl nicotinate with Ni-catalyst and then by methylation by action dimethyl sulfate) and 2-thienyl magnesium bromide was synthesized 1,1-di(thiophen-2-yl)-2-(3'-N-methylpiperidine), 3-(di-2-thienylmethylene)-1- methylpiperidine was obtained by dehydration of 1,1-di(thiophen-2-yl)-2-(3'- N-methylpiperidine) by action of base.
Therapeutic Function	Antitussive, Expectorant

tipepidine Preparation Products And Raw materials

Raw materials

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